Effect of Physical Training on Glucose Tolerance and on Glucose Metabolism of Skeletal Muscle in Anaesthetized Normal Rats

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1979 Mar 1

PMID 428688

Citations 14

Authors

M Berger

F W Kemmer

K Becker

L Herberg

M Schwenen

A Gjinavci

P Berchtold

Affiliations

Soon will be listed here.

Abstract

The effect of physical training on glucose tolerance in vivo and skeletal muscle glucose metabolism in vitro was investigated in normal rats. Treadmill running for 10 days up to 240 min/day led to a decrease of basal and glucose-stimulated plasma insulin levels without major alterations of the IV glucose tolerance (1 g/kg body weight). Swim training of two weeks' duration, i.e. exercise up to 2 X 75 min/day, which did not induce significant changes in body composition, skeletal muscle glycogen levels or citrate synthase activity, resulted in a significant improvement of IV glucose tolerance and substantial reductions of basal and glucose-stimulated plasma insulin levels. Associated with this apparent improvement of insulin sensitivity in vivo, significant increases of the insulin-stimulated glucose uptake (+ 55%) and lactate oxidation + 78%) in vitro were found on perfusion of the isolated hindquarter of swim-trained animals. It is suggested that mild physical training can improve glucose tolerance and insulin sensitivity in normal rats, at least in part, due to an increase of insulin sensitivity of skeletal muscle glucose metabolism.

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References

Berger M, Berchtold P, Gries F, Zimmermann H . [Significance of muscle work and training for therapy of diabetes mellitus]. Dtsch Med Wochenschr. 1978; 103(11):439-43. DOI: 10.1055/s-0028-1104454. View

Fitts R, Booth F, Winder W, Holloszy J . Skeletal muscle respiratory capacity, endurance, and glycogen utilization. Am J Physiol. 1975; 228(4):1029-33. DOI: 10.1152/ajplegacy.1975.228.4.1029. View

Holloszy J, Booth F . Biochemical adaptations to endurance exercise in muscle. Annu Rev Physiol. 1976; 38:273-91. DOI: 10.1146/annurev.ph.38.030176.001421. View

Berger M, Berchtold P, Cuppers H, DROST H, Kley H, Muller W . Metabolic and hormonal effects of muscular exercise in juvenile type diabetics. Diabetologia. 1977; 13(4):355-65. DOI: 10.1007/BF01223279. View

Bjorntorp P, Berchtold P, Grimby G, Lindholm B, SANNE H, Tibblin G . Effects of physical training on glucose tolerance, plasma insulin and lipids and on body composition in men after myocardial infarction. Acta Med Scand. 1972; 192(5):439-43. DOI: 10.1111/j.0954-6820.1972.tb04843.x. View

Berger M, Hagg S, Goodman M, Ruderman N . Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. Biochem J. 1976; 158(2):191-202. PMC: 1163959. DOI: 10.1042/bj1580191. View

Kemmer F, Berger M, Herberg L, Gries F . Effects of metformin on glucose metabolism of isolated perfused rat skeletal muscle. Arzneimittelforschung. 1977; 27(8):1573-6. View

Gould M, RAWLINSON W . Effect of natural exercise on pentose transport in rat skeletal muscle. Am J Physiol. 1966; 211(1):147-50. DOI: 10.1152/ajplegacy.1966.211.1.147. View

Herberg L, Kley H . Adrenal function and the effect of a high-fat diet on C57BL/6J and C57BL/6J-ob/ob mice. Horm Metab Res. 1975; 7(5):410-5. DOI: 10.1055/s-0028-1093695. View

10.

Lohmann D, Liebold F, HEILMANN W, Senger H, Pohl A . Diminished insulin response in highly trained athletes. Metabolism. 1978; 27(5):521-4. DOI: 10.1016/0026-0495(78)90017-3. View

11.

Trethewey J, Stewart G, Hanley T . The contribution of different organs and tissues of the rat to assimilation of glucose. Diabetologia. 1969; 5(6):384-91. DOI: 10.1007/BF00427976. View

12.

Karlsson J, Nordesjo L, Saltin B . Muscle glycogen utilization during exercise after physical training. Acta Physiol Scand. 1974; 90(1):210-7. DOI: 10.1111/j.1748-1716.1974.tb05579.x. View

13.

Berger M, Hagg S, Ruderman N . Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake. Biochem J. 1975; 146(1):231-8. PMC: 1165292. DOI: 10.1042/bj1460231. View

14.

Lipman R, Raskin P, Love T, Triebwasser J, LECOCQ F, Schnure J . Glucose intolerance during decreased physical activity in man. Diabetes. 1972; 21(2):101-7. DOI: 10.2337/diab.21.2.101. View

15.

Baldwin K, KLINKERFUSS G, Terjung R, Mole P, Holloszy J . Respiratory capacity of white, red, and intermediate muscle: adaptative response to exercise. Am J Physiol. 1972; 222(2):373-8. DOI: 10.1152/ajplegacy.1972.222.2.373. View

16.

Ruderman N, Houghton C, HEMS R . Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem J. 1971; 124(3):639-51. PMC: 1177234. DOI: 10.1042/bj1240639. View

17.

Montoye H, Block W, Metzner H, Keller J . Habitual physical activity and glucose tolerance. Males age 16-64 in a total community. Diabetes. 1977; 26(3):172-6. DOI: 10.2337/diab.26.3.172. View

18.

Mann G, Garrett H, Farhi A, Murray H, Billings F . Exercise to prevent coronary heart disease. An experimental study of the effects of training on risk factors for coronary disease in men. Am J Med. 1969; 46(1):12-27. DOI: 10.1016/0002-9343(69)90054-0. View

19.

Bjorntorp P, De Jounge K, Sjostrom L, Sullivan L . The effect of physical training on insulin production in obesity. Metabolism. 1970; 19(8):631-8. DOI: 10.1016/0026-0495(70)90020-x. View

20.

Bjorntorp P, Holm G, Jacobsson B, Lundberg P, Sjostrom L, Smith U . Physical training in human hyperplastic obesity. IV. Effects on the hormonal status. Metabolism. 1977; 26(3):319-28. DOI: 10.1016/0026-0495(77)90079-8. View