Adrenaline Synthesis: Control by the Pituitary Gland and Adrenal Glucocorticoids

Overview

Journal Science

Specialty Science

Date 1965 Dec 10

PMID 4285299

Citations 63

Authors

R J Wurtman

J Axelrod

Affiliations

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Abstract

The activity of phenylethanolamine-N-methyl transferase, an enzyme that synthesizes adrenaline from noradrenaline in the adrenal medulla, is markedly depressed following hypophysectomy. Enzyme activity is restored to normal after administration of ACTH or the potent glucocorticoid, dexamethasone. Thus the biosynthesis of adrenaline in the adrenal medulla appears to be regulated by the pituitary-adrenocortical system.

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