Regulation of Glucose Uptake by Muscle. 9. Effects of Fatty Acids and Ketone Bodies, and of Alloxan-diabetes and Starvation, on Pyruvate Metabolism and on Lactate-pyruvate and L-glycerol 3-phosphate-dihydroxyacetone Phosphate Concentration Ratios In...

Overview

Journal Biochem J

Specialty Biochemistry

Date 1964 Dec 1

PMID 4284560

Citations 59

Authors

P B Garland

E A Newsholme

P J Randle

Affiliations

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References

Bloom B, STETTEN M, STETTEN Jr D . Evaluation of catabolic pathways of glucose in mammalian systems. J Biol Chem. 1953; 204(2):681-94. View

Hiatt H, Goldstein M, LAREAU J, HORECKER B . The pathway of hexose synthesis from pyruvate in muscle. J Biol Chem. 1958; 231(1):303-7. View

Garland P, Randle P . Regulation of glucose uptake by muscles. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty.... Biochem J. 1964; 93(3):678-87. PMC: 1214026. DOI: 10.1042/bj0930678. View

Vallance-Owen J, DENNES E, CAMPBELL P . Insulin antagonism in plasma of diabetic patients and normal subjects. Lancet. 1958; 2(7042):336-8. DOI: 10.1016/s0140-6736(58)90257-5. View

Fry I, BUTTERFIELD W . Carbohydrate metabolism in diabetics. A possible intracellular block. Lancet. 1962; 2(7246):66-8. View

Randle P, Newsholme E, Garland P . Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem J. 1964; 93(3):652-65. PMC: 1214024. DOI: 10.1042/bj0930652. View

Randle P . Assay of plasma insulin activity by the rat-diaphragm method. Br Med J. 1954; 1(4873):1237-40. PMC: 2085067. DOI: 10.1136/bmj.1.4873.1237. View

Morgan H, Henderson M, REGEN D, Park C . Regulation of glucose uptake in muscle. I. The effects of insulin and anoxia on glucose transport and phosphorylation in the isolated, perfused heart of normal rats. J Biol Chem. 1961; 236:253-61. View

WOLLENBERGER A, Ristau O, SCHOFFA G . [A simple technic for extremely rapid freezing of large pieces of tissue]. Pflugers Arch Gesamte Physiol Menschen Tiere. 1960; 270:399-412. View

10.

Hales C, Randle P . Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 1963; 88:137-46. PMC: 1203862. DOI: 10.1042/bj0880137. View

11.

TROUT D, ESTES Jr E, FRIEDBERG S . Titration of free fatty acids of plasma: a study of current methods and a new modification. J Lipid Res. 1960; 1:199-202. View

12.

Weil R, ALTSZULER N, Kessler J . Effect of growth hormone on pyruvic acid metabolism. Am J Physiol. 1961; 201:251-4. DOI: 10.1152/ajplegacy.1961.201.2.251. View

13.

GLOCK G, McLean P . Effects of hormones on levels of oxidized and reduced diphosphopyridine nucleotide and triphosphopyridine nucleotide in liver and diaphragm. Biochem J. 1955; 61(3):397-402. PMC: 1215804. DOI: 10.1042/bj0610397. View

14.

Sheps M, Nickerson R, Dagenais Y, Steinke J, Martin D, Renold A . MEASUREMENT OF SMALL QUANTITIES OF INSULIN-LIKE ACTIVITY USING RAT ADIPOSE TISSUE. II. EVALUATION OF PERFORMANCE. J Clin Invest. 1960; 39(9):1499-510. PMC: 293396. DOI: 10.1172/JCI104169. View

15.

Newsholme E, Randle P . Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, on the concentrations of hexose phosphates, nucleotides and inorganic phosphate in.... Biochem J. 1964; 93(3):641-51. PMC: 1214023. DOI: 10.1042/bj0930641. View

16.

VILLEE C, HASTINGS A . The utilization in vitro of C14-labeled acetate and pyruvate by diaphragm muscle of rat. J Biol Chem. 1949; 181(1):131-9. View

17.

Newsholme E, Randle P . Regulation of glucose uptake by muscle. 6. Fructose 1,6-diphosphatase activity of rat heart and rat diaphragm. Biochem J. 1962; 83(2):387-92. PMC: 1243562. DOI: 10.1042/bj0830387. View

18.

Short D, Parkes A . Feeding and breeding of laboratory animals; a compound diet for monkeys. J Hyg (Lond). 1949; 47(2):209-12. PMC: 2234928. DOI: 10.1017/s0022172400014480. View

19.

Garland P, Newsholme E, Randle P . Effect of fatty acids, ketone bodies, diabetes and starvation on pyruvate metabolism in rat heart and diaphragm muscle. Nature. 1962; 195:381-3. DOI: 10.1038/195381a0. View