Mutation in Neurospora Crasa Affecting Some of the Extracellular Enzymes and Several Growth Characteristics

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1973 Sep 1

PMID 4269585

Citations 9

Authors

T Murayama

T Ishikawa

Affiliations

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Abstract

A mutant of Neurospora crassa, strain T9, which shows reduced activity of glucoamylase, was isolated. The mutant glucoamylase was not altered in pH optimum, or thermostability, but altered in elution profile of Bio-Gel filtration. The T9 mutation led to other distinct phenotypic effects: a poor growth response, resistance to the effect of sorbose, a high activity of extracellular acid phosphatase, and an increased sensitivity to high osmolarity of the growth medium. The discussion was based on the idea that the T9 mutation occurred at a gene governing the synthesis of cell wall precursors and resulted in an alteration in various characteristics related to extracellular enzymes and growth.

Citing Articles

Structural and kinetic alterations of constitutive conidial alkaline phosphatase from the osmotically-sensitive mutant of Neurospora crassa.

Bogo K, Masui D, Leone F, Jorge J, Furriel R Folia Microbiol (Praha). 2006; 51(5):431-7.

PMID: 17176763 DOI: 10.1007/BF02931587.

Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.

Borkovich K, Alex L, Yarden O, Freitag M, Turner G, Read N Microbiol Mol Biol Rev. 2004; 68(1):1-108.

PMID: 15007097 PMC: 362109. DOI: 10.1128/MMBR.68.1.1-108.2004.

A possible rôle for acid phosphatase in gamma-amino-n-butyrate uptake in Aspergillus nidulans.

Arst Jr H, Bailey C, Penfold H Arch Microbiol. 1980; 125(1-2):153-8.

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Isolation and characterization of Neurospora mutants affected in invertase synthesis.

Lee D, Free S Genetics. 1984; 106(4):591-9.

PMID: 6232169 PMC: 1202291. DOI: 10.1093/genetics/106.4.591.

Chromosomal loci of Neurospora crassa.

Perkins D, Radford A, Newmeyer D, Bjorkman M Microbiol Rev. 1982; 46(4):426-570.

PMID: 6219280 PMC: 281555. DOI: 10.1128/mr.46.4.426-570.1982.

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