A Suggested Mechanism for the Pathogenesis of Infectious Atrophic Rhinitis

Overview

Journal Can J Comp Med

Specialty Veterinary Medicine

Date 1971 Oct 1

PMID 4260946

Citations 6

Authors

D L Harris

W P Switzer

R A Harris

Affiliations

Soon will be listed here.

Abstract

Boivin extracts of Bordetella bronchiseptica inhibited or uncoupled the energized processes of bovine heart and pig heart mitochondria. Energy-dependent accumulation of calcium phosphate by both types of mitochondria was markedly inhibited by the extracts. The thesis is advanced that Boivin extracts of B. bronchiseptica may contain the membrane-damaging component responsible for infectious atrophic rhinitis. The action of the extracts was decreased by heat but seemed rather insensitive to digestion by trypsin or extraction by lipid solvents. Attempts to resolve the active component from the extracts were unsuccessful.

Citing Articles

Experimental atrophic rhinitis in gnotobiotic pigs.

Miniats O, Johnson J Can J Comp Med. 1980; 44(4):358-65.

PMID: 7448626 PMC: 1320090.

Biology of Bordetella bronchiseptica.

Goodnow R Microbiol Rev. 1980; 44(4):722-38.

PMID: 7010115 PMC: 373201. DOI: 10.1128/mr.44.4.722-738.1980.

Influence of potential virulence determinants on Bordetella bronchiseptica-induced ciliostasis.

Bemis D, Wilson S Infect Immun. 1985; 50(1):35-42.

PMID: 2864315 PMC: 262131. DOI: 10.1128/iai.50.1.35-42.1985.

Human infections associated with Bordetella bronchiseptica.

WOOLFREY B, Moody J Clin Microbiol Rev. 1991; 4(3):243-55.

PMID: 1889042 PMC: 358197. DOI: 10.1128/CMR.4.3.243.

An agglutination test for the detection of Bordetella bronchiseptica infection in swine.

Jenkins E Can J Comp Med. 1978; 42(3):286-92.

PMID: 688071 PMC: 1277640.

References

Duncan J, RAMSEY F . Fine structural changes in the porcine nasal ciliated epithelial cell produced by Bordetella bronchiseptica rhinitis. Am J Pathol. 1965; 47(4):601-12. PMC: 1920459. View

MILNER K, Finkelstein R . Bioassay of endotoxin: correlation between pyrogenicity for rabbits and lethality for chick embryos. J Infect Dis. 1966; 116(5):529-36. DOI: 10.1093/infdis/116.5.529. View

Duncan J, Ross R, Switzer W, RAMSEY F . Pathology of experimental Bordetella bronchiseptica infection in swine: atrophic rhinitis. Am J Vet Res. 1966; 27(117):457-66. View

Ozawa T . Adenosine monophosphate as the first phosphoryl acceptor in oxidative phosphorylation. Arch Biochem Biophys. 1966; 117(2):201-23. DOI: 10.1016/0003-9861(66)90405-x. View

Harris D, Switzer W . Turbinate atrophy in young pigs exposed to Bordetella bronchiseptica, Pasteurella multocida, and combined inoculum. Am J Vet Res. 1968; 29(4):777-85. View

Harris R, Harris D, Green D . Effect of Bordetella endotoxin upon mitochondrial respiration and energized processes. Arch Biochem Biophys. 1968; 128(1):219-30. DOI: 10.1016/0003-9861(68)90025-8. View

Shapiro I, Greenspan J . Are mitochondria directly involved in biological mineralisation?. Calcif Tissue Res. 1969; 3(1):100-2. DOI: 10.1007/BF02058651. View

Harris D, Ross R, Switzer W . Incidence of certain microorganisms in nasal cavities of swine in Iowa. Am J Vet Res. 1969; 30(9):1621-4. View

Morse J, Morse S . Studies on the ultrastructure of Bordetella pertussis. I. Morphology, origin, and biological activity of structures present in the extracellular fluid of liquid cultures of Bordetella pertussis. J Exp Med. 1970; 131(6):1342-57. PMC: 2138840. DOI: 10.1084/jem.131.6.1342. View

10.

Rasmussen H . Cell communication, calcium ion, and cyclic adenosine monophosphate. Science. 1970; 170(3956):404-12. DOI: 10.1126/science.170.3956.404. View

11.

Fetter A, Capen C . Fine structure of bone cells in the nasal turbinates of pigs with naturally occurring atrophic rhinitis. Am J Pathol. 1971; 62(2):265-82. PMC: 2047541. View

12.

Fetter A, Capen C . Ultrastructural evaluation of bone cells in pigs with experimental turbinate osteoporosis (atrophic rhinitis). Lab Invest. 1971; 24(5):392-403. View

13.

Ernster L, Lindberg O . Determination of organic phosphorus compounds by phosphate analysis. Methods Biochem Anal. 1956; 3:1-22. DOI: 10.1002/9780470110195.ch1. View

14.

Crane F, Glenn J, Green D . Studies on the electron transfer system. IV. The electron transfer particle. Biochim Biophys Acta. 1956; 22(3):475-87. DOI: 10.1016/0006-3002(56)90058-0. View

15.

HATEFI Y, Lester R . Studies on the mechanism of oxidative phosphorylation. III. Phosphorylating particle types from beef heart. Biochim Biophys Acta. 1958; 27(1):83-8. DOI: 10.1016/0006-3002(58)90294-4. View

16.

BENNETT Jr I, Cluff L . Bacterial pyrogens. Pharmacol Rev. 1957; 9(4):427-79. View

17.

Cross R . Bordetella bronchiseptica-induced porcine atrophic rhinitis. J Am Vet Med Assoc. 1962; 141:1467-8. View

18.

Switzer W . Studies on infectious atrophic rhinitis of swine. III. Review of literature. J Am Vet Med Assoc. 1955; 127(943):340-8. View

19.

Switzer W . Studies on infectious atrophic rhinitis. V. Concept that several agents may cause turbinate atrophy. Am J Vet Res. 1956; 17(64):478-84. View