Supersensitivity to Opioids Following the Chronic Blockade of Endorphin Action by Naloxone

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1979 Jan 31

PMID 424002

Citations 9

Authors

R Schulz

M Wuster

A Herz

Affiliations

Soon will be listed here.

Abstract

Chronic treatment of guinea pigs with the narcotic antagonist naloxone (pellet implantation technique) caused an increased sensitivity to opioids of the electrically stimulated longitudinal muscle-myenteric plexus preparation of the ileum. This supersensitivity is associated with an elevation of the total number of opiate receptor binding sites in both the peripheral and the central nervous system.

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