Generalized Gangliosidosis: Impaired Cleavage of Galactose from a Mucopolysaccharide and a Glycoprotien

Overview

Journal Science

Specialty Science

Date 1969 Feb 28

PMID 4236799

Citations 10

Authors

M C MACBRINN

S Okada

M W Ho

C C Hu

J S OBrien

Affiliations

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Abstract

We have demonstrated a tenfold (or greater) reduction of the cleavage of galactose from a mucopolysaccharide and a glycoprotein in generalized gangliosidosis, a lysosomal beta-galactosidase deficiency disease. The bony abnormalities in this disease may be due to defective catabolism of mucopolysaccharides in connective tissue.

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