Hurler and Hunter Syndromes: Mutual Correction of the Defect in Cultured Fibroblasts

Overview

Journal Science

Specialty Science

Date 1968 Nov 1

PMID 4236721

Citations 140

Authors

J C Fratantoni

C W Hall

E F Neufeld

Affiliations

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Abstract

The biochemical defect of cultuired skin fibroblasts from Hurler or Hunter patients (faulty degradation of sulfated mucopolysaccharide, resulting in excessive intracellular accumulation) may be corrected if cells of these two genotypes are mixed with each other or with normal cells. The effect is mediated by substances released into the medium.

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