Superoxide Dismutase and Glutathione Peroxidase in Polymorphonuclear Leucocytes

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 1979 Feb 8

PMID 421692

Citations 3

Authors

M Rister

K Bauermeister

U Gravert

E GLADTKE

Affiliations

Soon will be listed here.

Abstract

Superoxide dismutase (SOD) and glutathione peroxidase (GPX) protect aerobic organisms against the toxic superoxide anion and hydrogen peroxide, which are generated during phagocytosis by polymorphonuclear leucocytes (PMNs). PMNs of children with bacterial infections and with infectious hepatitis contained significantly elevated SOD activity, whereas GPX activity remained in the normal range. In contrast, PMNs of children with viral infections and rheumatoid arthritis exhibited a decreased SOD activity, while GPX activity was again unchanged. The children's age, sex or treatment did not effect the enzyme activities in PMNs. Since SOD generates bactericidal hydrogen peroxide and regulates the release of the toxic superoxide radical into the surrounding tissues, this study may add new understanding to the pathophysiological aspects of acute and chronic inflammatory processes.

Citing Articles

Concanavalin A capping in polymorphonuclear leukocytes.

Rister M, Brucke G, Wegener F, GLADTKE E Eur J Pediatr. 1980; 135(2):153-60.

PMID: 7192630 DOI: 10.1007/BF00441634.

[Superoxide-dismutase and superoxide-radical-release in rheumatoid arthritis (author's transl)].

Rister M, Bauermeister K Klin Wochenschr. 1982; 60(11):561-5.

PMID: 6287090 DOI: 10.1007/BF01724212.

Diminished neutrophil function in Crohn's disease and ulcerative colitis identified by decreased oxidative metabolism and low superoxide dismutase content.

Verspaget H, Pena A, Weterman I, Lamers C Gut. 1988; 29(2):223-8.

PMID: 2831119 PMC: 1433298. DOI: 10.1136/gut.29.2.223.

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