Inhibition of Prostaglandin Biosynthesis by 7-oxa- and 5-oxa-prostaglandin Analogues

Overview

Journal Biochem J

Specialty Biochemistry

Date 1973 Jan 1

PMID 4198692

Authors

R G McDonald-Gibson

J D Flack

P W RAMWELL

Affiliations

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Abstract

Some oxaprostaglandin derivatives have been shown to inhibit prostaglandin biosynthesis from arachidonate by a particulate prostaglandin synthetase preparation. The most potent inhibitor was 5-oxaprost-13-trans-enoate, and inhibition by this compound appeared to be competitive. Certain structure-activity relationships were ascertained.

References

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