Attenuation of Stereotyped Behaviour by Sex Steroids

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1978 Apr 28

PMID 418456

Citations 6

Authors

S R Naik

M R Kelkar

U K sheth

Affiliations

Soon will be listed here.

Abstract

Effects of sex steroids, testosterone, progesterone, and estradiol on PEA-induced stereotyped behaviour (SB) has been studied in normal, castrated, and ovariectomised mice. Effects of sex steroids on amphetamine-induced sterotypy and hyperactivity are also described. In castrated and ovariectomised mice B-phenylethylamine (PEA) increased SB. Pretreatment with sex steroids attenuated PEA-induced stereotypy in normal, castrated, and ovarietomised mice. Sex steroid pretreatment significantly inhibited PEA- and amphetamine-induced SB, but failed to alter increased motor activity due to amphetamine or PEA. The possible effect of sec steroids on SB through changes in central neurotransmitters are discussed.

Citing Articles

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Contrasting effects of increased and decreased dopamine transmission on latent inhibition in ovariectomized rats and their modulation by 17beta-estradiol: an animal model of menopausal psychosis?.

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Disruption of latent inhibition induced by ovariectomy can be reversed by estradiol and clozapine as well as by co-administration of haloperidol with estradiol but not by haloperidol alone.

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Effects of ovariectomy, castration, and chronic lithium chloride treatment on stereotyped behavior in rats.

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