Neutralization of Sensitized Virus by the Fourth Component of Complement

Overview

Journal Science

Specialty Science

Date 1969 Aug 1

PMID 4183180

Citations 22

Authors

C A Daniels

T Borsos

H J Rapp

R Snyderman

A L Notkins

Affiliations

Soon will be listed here.

Abstract

Herpes simplex virus which had been sensitized with IgM antibody was not neutralized by the addition of the purified activated first component of complement. In the presence of an optimum concentration of the first component of complement, however, the sensitized virus was neutralized by the addition of a high concentration of the purified fourth component of complement. Under these conditions, the addition of the purified second and third components of complement failed to enhance virus neutralization. With low concentrations of the fourth component of complement, the addition of the second and third components enhanced virus neutralization.

Citing Articles

Antibody and complement-dependent viral neutralization.

Cooper N, Welsh Jr R Springer Semin Immunopathol. 2020; 2(3):285-310.

PMID: 32214620 PMC: 7087519. DOI: 10.1007/BF00198721.

Complement protein C1q reduces the stoichiometric threshold for antibody-mediated neutralization of West Nile virus.

Mehlhop E, Nelson S, Jost C, Gorlatov S, Johnson S, Fremont D Cell Host Microbe. 2009; 6(4):381-91.

PMID: 19837377 PMC: 2782387. DOI: 10.1016/j.chom.2009.09.003.

Complement modulates pathogenesis and antibody-dependent neutralization of West Nile virus infection through a C5-independent mechanism.

Mehlhop E, Fuchs A, Engle M, Diamond M Virology. 2009; 393(1):11-5.

PMID: 19744691 PMC: 2753729. DOI: 10.1016/j.virol.2009.08.019.

Secretory immunoglobulin a and herpes keratitis.

Centifanto Y, Kaufman H Infect Immun. 1970; 2(6):778-82.

PMID: 16557916 PMC: 416091. DOI: 10.1128/iai.2.6.778-782.1970.

Genetic bases of autoimmune hepatitis.

Czaja A, Doherty D, Donaldson P Dig Dis Sci. 2002; 47(10):2139-50.

PMID: 12395884 DOI: 10.1023/a:1020166605016.