Effects of Medial Raphe and Raphe Magnus Lesions on the Analgesic Activity of Morphine and Methadone

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1978 Mar 1

PMID 417364

Citations 11

Authors

W T Chance

G M Krynock

J A ROSECRANS

Affiliations

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Abstract

The effects of lesions of the raphe nuclei on opiate-induced antinociception and brain serotonin (5-HT) levels were investigated. Lesions of the medial raphe nucleus effectively antagonized the analgesic effects of morphine, but not methadone, and lowered brain 5-HT. The decrement in analgesic activity of morphine was reversed by pretreatment with 5-hydroxytryptophan. Lesions of the raphe magnus, a descending 5-HT system, antagonized the analgesic potency of both morphine and methadone. These experiments indicate a differential effect of 5-HT manipulation on opiate-induced analgesia, suggesting a different mechanism of analgesic action for morphine and methadone.

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