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Association of Experimental Chronic Arthritis with the Persistence of Group A Streptococcal Cell Walls in the Articular Tissue

Overview
Journal J Bacteriol
Publisher American Society for Microbiology
Specialty Microbiology
Date 1967 Nov 1
PMID 4169223
Citations 37
Authors
J H Schwab
W J CROMARTIE
S H Ohanian
J G CRADDOCK
Affiliations
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Abstract

A single injection of isolated fragments of group A streptococcal cell walls into the joints of rabbits stimulated an initial acute reaction which was followed by a prolonged inflammatory process. The chronic process was characterized by hyperplasia of the synovial cells, diffuse infiltration of the villi by macrophages, and focal collections of lymphocytes in the stroma of the villi. These histological changes were similar to those seen in the early stages of rheumatoid arthritis. Antibodies specific for the mucopeptide and group-specific C polysaccharide antigens of group A streptococcal cell walls were labeled with either fluorescein or (125)I, and were used to demonstrate antigen in the synovial tissues. The antigens persisted within macro-phages for at least 5 weeks. Their presence correlated with the evolution of the chronic inflammatory process.

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References
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Abdulla E, Schwab J . Biological properties of streptococcal cell-wall particles. 3. Dermonecrotic reaction to cell-wall mucopeptides. J Bacteriol. 1966; 91(1):374-83. PMC: 315957. DOI: 10.1128/jb.91.1.374-383.1966. View
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Schwab J, CROMARTIE W . Studies on a toxic cellular component of group A streptococci. J Bacteriol. 1957; 74(5):673-9. PMC: 289979. DOI: 10.1128/jb.74.5.673-679.1957. View
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Ohanian S, Schwab J . Persistence of group a streptococcal cell walls related to chronic inflammation of rabbit dermal connective tissue. J Exp Med. 1967; 125(6):1137-48. PMC: 2138277. DOI: 10.1084/jem.125.6.1137. View