Evidence That Punctate Intracerebral Administration of 6-hydroxydopamine Fails to Produce Selective Neuronal Degeneration. Comparison with Copper Sulfate and Factors Governing the Deportment of Fluids Injected into Brain

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1974 Jan 1

PMID 4155050

Citations 9

Authors

L L Butcher

S M Eastgate

G K Hodge

Affiliations

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Relationship between sensorimotor neglect and the specificity, degree and locus of mesotelencephalic dopaminergic cell loss following 6-hydroxydopamine.

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Trypan blue in vivo stains nigral dopaminergic neurons killed by 6-hydroxydopamine.

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Histopathologic changes associated with intracerebral injections of 6-hydroxydopamine (6-OHDA) and peroxide (H2O2) in the cat and the rat.

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References

Kim J . Effects of 6-hydroxydopamine on acetylcholine and GABA metabolism in rat striatum. Brain Res. 1973; 55(2):472-5. DOI: 10.1016/0006-8993(73)90316-8. View

McGeer P, McGeer E, Fibiger H, Wickson V . Neostriatal choline acetylase and cholinesterase following selective brain lesions. Brain Res. 1971; 35(1):308-14. DOI: 10.1016/0006-8993(71)90625-1. View

Evetts K, Iversen L . Effects of protriptyline on the depletion of catecholamines induced by 6-hydroxydopamine in the brain of the rat. J Pharm Pharmacol. 1970; 22(7):540-3. DOI: 10.1111/j.2042-7158.1970.tb10564.x. View

Sotelo C, JAVOY F, Agid Y, Glowinski J . Injection of 6-hydroxydopamine in the substantia nigra of the rat. I. Morphological study. Brain Res. 1973; 58(2):269-90. DOI: 10.1016/0006-8993(73)90001-2. View

Moore R, Bhatnagar R, Heller A . Anatomical and chemical studies of a nigro-neostriatal projection in the cat. Brain Res. 1971; 30(1):119-35. DOI: 10.1016/0006-8993(71)90009-6. View

Hedreen J, Chalmers J . Neuronal degeneration in rat brain induced by 6-hydroxydopamine; a histological and biochemical study. Brain Res. 1972; 47(1):1-36. DOI: 10.1016/0006-8993(72)90248-x. View

Breese G, Kopin I, Weise V . Effects of amphetamine derivatives on brain dopamine and noradrenaline. Br J Pharmacol. 1970; 38(3):537-45. PMC: 1702572. DOI: 10.1111/j.1476-5381.1970.tb10595.x. View

Thoenen H, Tranzer J . The pharmacology of 6-hydroxydopamine. Annu Rev Pharmacol. 1973; 13:169-80. DOI: 10.1146/annurev.pa.13.040173.001125. View

Ungerstedt U . Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand Suppl. 1971; 367:1-48. DOI: 10.1111/j.1365-201x.1971.tb10998.x. View

10.

Hokfelt T, Ungerstedt U . Specificity of 6-hydroxydopamine induced degeneration of central monoamine neurones: an electron and fluorescence microscopic study with special reference to intracerebral injection on the nigro-striatal dopamine system. Brain Res. 1973; 60(2):269-97. DOI: 10.1016/0006-8993(73)90791-9. View

11.

Karnovsky M, ROOTS L . A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES. J Histochem Cytochem. 1964; 12:219-21. DOI: 10.1177/12.3.219. View

12.

Miller R, Strominger N . Efferent connections of the red nucleus in the brainstem and spinal cord of the Rhesus monkey. J Comp Neurol. 1973; 152(4):327-45. DOI: 10.1002/cne.901520403. View

13.

Porter C, TOTARO J, Stone C . Effect of 6-hydroxydopamine and some other compounds on the concentration of norepinephrine in the hearts of mice. J Pharmacol Exp Ther. 1963; 140:308-16. View

14.

POIRIER L, Langelier P, Roberge A, Boucher R, Kitsikis A . Non-specific histopathological changes induced by the intracerebral injection of 6-hydroxy-dopamine (6-OH-DA). J Neurol Sci. 1972; 16(4):401-16. DOI: 10.1016/0022-510x(72)90047-0. View

15.

Lynch G, Lucas P, Deadwyler S . The demonstration of acetylcholinesterase containing neurones within the caudate nucleus of the rat. Brain Res. 1972; 45(2):617-21. DOI: 10.1016/0006-8993(72)90494-5. View

16.

Maler L, Fibiger H, McGeer P . Demonstration of the nigrostriatal projection by silver staining after nigral injections of 6-hydroxydopamine. Exp Neurol. 1973; 40(2):505-15. DOI: 10.1016/0014-4886(73)90091-5. View

17.

Ungerstedt U, Butcher L, Butcher S, ANDEN N, Fuxe K . Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat. Brain Res. 1969; 14(2):461-71. DOI: 10.1016/0006-8993(69)90122-x. View

18.

Jonsson G, Sachs C . Degenerative and nondegenerative effects of 6-hydroxydopamine on adrenergic nerves. J Pharmacol Exp Ther. 1972; 180(3):625-35. View

19.

Kemp J, Powell T . The structure of the caudate nucleus of the cat: light and electron microscopy. Philos Trans R Soc Lond B Biol Sci. 1971; 262(845):383-401. DOI: 10.1098/rstb.1971.0102. View

20.

Agid Y, JAVOY F, Glowinski J, Bouvet D, Sotelo C . Injection of 6-hydroxydopamine into the substantia nigra of the rat. II. Diffusion and specificity. Brain Res. 1973; 58(2):291-301. DOI: 10.1016/0006-8993(73)90002-4. View