Metabolic Activation of Halothane and Its Covalent Binding to Liver Endoplasmic Proteins in Vitro

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1973 Aug 24

PMID 4147966

Citations 12

Authors

H UEHLEKE

K H Hellmer

Affiliations

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Citing Articles

Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation.

Kappus H, Sies H Experientia. 1981; 37(12):1233-41.

PMID: 7035210 DOI: 10.1007/BF01948335.

The mechanism of halothane binding to microsomal cytochrome P450.

Mansuy D, Nastainczyk W, Ullrich V Naunyn Schmiedebergs Arch Pharmacol. 1974; 285(4):315-24.

PMID: 4280521 DOI: 10.1007/BF00501461.

Characterization of a halothane-induced humoral immune response in rabbits.

Callis A, Brooks S, Roth T, Gandolfi A, Brown B Clin Exp Immunol. 1987; 67(2):343-51.

PMID: 3608227 PMC: 1542605.

Clinical pharmacokinetics of the inhalational anaesthetics.

Dale O, Brown Jr B Clin Pharmacokinet. 1987; 12(3):145-67.

PMID: 3555939 DOI: 10.2165/00003088-198712030-00001.

Chronology of halothane-induced antigen expression in halothane-exposed rabbits.

Roth T, Hubbard A, Gandolfi A, Brown B Clin Exp Immunol. 1988; 72(2):330-6.

PMID: 3409550 PMC: 1541549.

References

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Ullrich V, Schnabel K . Formation and binding of carbanions by cytochrome P-450 of liver microsomes. Drug Metab Dispos. 1973; 1(1):176-83. View

. Halothane: hepatitis or allergy?. Lancet. 1969; 1(7602):975-6. View

Reiner O, Athanassopoulos S, Hellmer K, Murray R, UEHLEKE H . [Formation of chloroform from carbon tetrachloride in liver microsomes, lipid peroxidation and destruction of cytochrome P-450]. Arch Toxikol. 1972; 29(3):219-33. View

Dykes M, Gilbert J, Schur P, Cohen E . Halothane and the liver: a review of the epidemiologic, immunologic and metabolic aspects of the relationship. Can J Surg. 1972; 15(4):217-38. View

UEHLEKE H, Hellmer K, Tabarelli S . Binding of 14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3 by reduced liver microsomes. Xenobiotica. 1973; 3(1):1-11. DOI: 10.3109/00498257309151495. View

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UEHLEKE H, Schnitger F, Hellmer K . [Behavior of different microsomal drug oxidations following inactivation of cytochrome P-450 by UV-irradiation or deoxycholate treatment]. Hoppe Seylers Z Physiol Chem. 1970; 351(12):1475-84. View

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Schnitger F, UEHLEKE H . [Influence of diethylnitrosamine, carbon tetrachloride, butter yellow and cyclophosphamide on amino acid incorporation into fractions of liver homogenates after metabolic activation in vitro. Possibilities for the detection of hepatotoxic effects]. Arch Toxikol. 1969; 25(2):169-82. View

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UEHLEKE H, Greim H . [Stimulation of drug oxidation in kidney microsomes by phenobarbital]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968; 261(2):152-61. View

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