Open-field Behavior After Intravenous Amphetamine Analogues in Rats

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1977 Dec 19

PMID 414270

Citations 2

Authors

M P Lindquist

K G Gotestam

Affiliations

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Abstract

A variety of behaviors were studied in an open-field setting after i.v. amphetamine (0.5, 2.0, 8.0 mg/kg), phenmetrazine (1.0, 4.0, 16.0 mg/kg), or fenfluramine (1.0, 4.0, 16.0 mg/kg). Amphetamine and phenmetrazine increased ambulation initially and rearing during the whole experiment, and decreased grooming. At 30 and 60 min, with the three higher doses of amphetamine, stereotyped behaviors interfered with and decreased both ambulation and groomin. Fenfluramine decreased ambulation, rearing, and grooming, and was the only drug to induce backing. The technique seems to be a simple and rapid method to establish dependence liability in amphetamine analogues. Interrater and test-retest reliability was established through ITV recordings.

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Keegan B, Dreitzler A, Sexton T, Beveridge T, Smith H, Miller M Brain Res. 2021; 1761:147387.

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Suppression of behavioral activity by norfenfluramine and related drugs in rats is not mediated by serotonin release.

Callaway C, Wing L, Nichols D, Geyer M Psychopharmacology (Berl). 1993; 111(2):169-78.

PMID: 7870948 DOI: 10.1007/BF02245519.

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