The Effect of Delta 9-tetrahydrocannabinol, Cannabidiol, and Cannabinol on the Anaesthesia Induced by Various Anaesthetic Agents in Mice

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1977 Nov 24

PMID 414255

Citations 7

Authors

J Frizza

G B Chesher

D M Jackson

R Malor

G A Starmer

Affiliations

Soon will be listed here.

Abstract

delta 9-Tetrahydrocannabinol (2.5-80.0 mg/kg) significantly prolonged the anaesthesia induced by ketamine, pentobarbitone, thiopentone, propanidid, and Alfathesin in a dose-dependent manner. Cannabinol and cannabidiol (both 5.0-80.0 mg/kg) were essentially inactive, except that cannabidiol prolonged pentobarbitone-induced anaesthesia. The interaction of delta 9-tetrahydrocannabinol with the anaesthetic agents was postulated to be due to a centrally mediated action, whereas the effect of cannabidiol on pentobarbitone-induced anaesthesia probably depended on a metabolic interaction. The interaction between the cannabinoids in influencing anaesthesia induced by the above agents was examined, and the interactions were found to be complex.

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