Phenoxazinone Synthetase from Streptomyces Antibioticus: Multiple Activities of the Enzyme

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1972 Dec 1

PMID 4118295

Citations 1

Authors

E E Golub

J S NISHIMURA

Affiliations

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Abstract

A procedure for the preparation of relatively large quantities of highly purified phenoxazinone synthetase from Streptomyces antibioticus is described. Enzyme preparations consisted of multiple forms, as determined by polyacrylamide gel electrophoresis. Each of the electrophoretically separable forms catalyzed the oxidation of catechols, ferrocyanide, and ethylenic thiols, in addition to o-aminophenols.

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PMID: 27239225 PMC: 4884384. DOI: 10.1186/s13065-016-0178-8.

References

Friedman S, Kaufman S . 3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity. J Biol Chem. 1965; 240(12):4763-73. View

Friedman S, Kaufman S . An electron paramagnetic resonance study of 3,4-dihydroxyphenylethylamine beta-hydroxylase. J Biol Chem. 1966; 241(10):2256-9. View

JOLLEY Jr R, Robb D, Mason H . The multiple forms of mushroom tyrosinase. Association-dissociation phenomena. J Biol Chem. 1969; 244(6):1593-9. View

SALZMAN L, Weissbach H, Katz E . Enzymatic synthesis of actinocinyl peptides. Arch Biochem Biophys. 1969; 130(1):536-46. DOI: 10.1016/0003-9861(69)90067-8. View

NISHIMURA J, Golub E . On the effects of cyanide on phenoxazinone synthetase. Biochim Biophys Acta. 1969; 191(3):724-6. DOI: 10.1016/0005-2744(69)90369-6. View

SWINGLE S, TISELIUS A . Tricalcium phosphate as an adsorbent in the chromatography of proteins. Biochem J. 1951; 48(2):171-4. PMC: 1275500. DOI: 10.1042/bj0480171. View

LOWRY O, ROSEBROUGH N, FARR A, RANDALL R . Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1):265-75. View

Goss W, Katz E . Actinomycin formation by Streptomyces cultures. Appl Microbiol. 1957; 5(2):95-102. PMC: 1057265. DOI: 10.1128/am.5.2.95-102.1957. View

LEVIN E, Kaufman S . Studies on the enzyme catalyzing the conversion of 3,4-dihydroxyphenylethylamine to norepinephrine. J Biol Chem. 1961; 236:2043-9. View

10.

Katz E, Weissbach H . Biosynthesis of the actinomycin chromophore; enzymatic conversion of 4-methyl-3-hydroxyanthranilic acid to actinocin. J Biol Chem. 1962; 237:882-6. View

11.

FLING M, HOROWITZ N, Heinemann S . The isolation and properties of crystalline tyrosinase from Neurospora. J Biol Chem. 1963; 238:2045-53. View

12.

Bouchilloux S, MCMAHILL P, Mason H . The multiple forms of mushroom tyrosinase. Purification and molecular properties of the enzymes. J Biol Chem. 1963; 238:1699-707. View

13.

Davis B . DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS. Ann N Y Acad Sci. 1964; 121:404-27. DOI: 10.1111/j.1749-6632.1964.tb14213.x. View

14.

Aurbach G, Jakoby W . The multiple functions of thiooxidase. J Biol Chem. 1962; 237:565-8. View