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Experimental Salmonellosis: Hypersensitivity to Cell Wall Lipopolysaccharide and Anti-infectious Resistance of Mice Infected with Salmonella

Overview
Journal Infect Immun
Publisher American Society for Microbiology
Specialty Allergy & Immunology
Date 1971 Nov 1
PMID 4117290
Citations 3
Authors
M Kawakami
Y Hara
N Osawa
Affiliations
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Abstract

Mice infected with various strains of Salmonella enteritidis and S. typhimurium were found to be more sensitive to the cell wall lipopolysaccharide (LPS) extracted from certain strains of Salmonella than noninfected mice. This hypersensitivity was induced by those smooth or rough strains which possessed a polysaccharide chain longer than that of a glucoseless mutant. The major antigenic group participating in this hypersensitivity was presumed to be in rough core polysaccharide sequence because fractions containing either O side chain or LPS of a heptoseless mutant were ineffective in provoking a hypersensitivity reaction. Conditions for the induction and the phases of development of this hypersensitivity to LPS and for anti-infectious resistance were shown to be different. Present and previously obtained results suggest that the antigens participating in each of these two conditions were different.

Citing Articles

Toxicity of lipopolysaccharide and of soluble extracts of Salmonella typhimurium in mice immunized with a live attenuated aroA salmonella vaccine.

Mastroeni P, Villarreal-Ramos B, Harrison J, Demarco de Hormaeche R, Hormaeche C Infect Immun. 1994; 62(6):2285-8.

PMID: 8188350 PMC: 186509. DOI: 10.1128/iai.62.6.2285-2288.1994.

Inverse relationship between the susceptibility of lipopolysaccharide (lipid A)-pretreated mice to the hypothermic and lethal effect of lipopolysaccharide.

Greer G, Rietschel E Infect Immun. 1978; 20(2):366-74.

PMID: 669802 PMC: 421864. DOI: 10.1128/iai.20.2.366-374.1978.

Lipid A-induced tolerance and hyperreactivity to hypothermia in mice.

Greer G, Rietschel E Infect Immun. 1978; 19(2):357-68.

PMID: 631875 PMC: 414090. DOI: 10.1128/iai.19.2.357-368.1978.

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