S-adenosyl-L-methionine Protection Against Alpha-naphthylisothiocyanate-induced Cholestasis in the Rat

Overview

Journal Toxicol Lett

Publisher Elsevier

Specialty Toxicology

Date 1985 Dec 1

PMID 4089881

Citations 5

Authors

C Di Padova

F Di Padova

R Tritapepe

G Stramentinoli

Affiliations

Soon will be listed here.

Abstract

The effect of S-adenosyl-L-methionine (SAMe) on cholestasis induced by alpha-naphthylisothiocyanate (ANIT) was studied in rats. SAMe significantly attenuated both bile flow impairment and elevated values of serum bilirubin, glutamic pyruvic transaminase and alkaline phosphatase in ANIT-treated animals. These results suggest that SAMe protects the rat liver against the toxic effects of ANIT.

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