Prostate Cancer in a Sprague-Dawley Rat

An adenocarcinoma of the prostate gland developed in one rat of the Lobund Sprague-Dawley (S-D) strain, following treatments with testosterone propionate in silastic membranes. The transplanted cells (PA-SD1) developed local tumors, metastasized through lymphatic channels to the lungs, and induced osteolytic lesions when deposited adjacent to the calvarium. In vitro-propagated PA-SD1 cells produced the same tumor type in Lobund strain S-D rats as that from which it was derived.