Cigarette Smoking and Duodenal Ulcer

Overview

Journal Gut

Specialty Gastroenterology

Date 1985 Dec 1

PMID 4085909

Citations 6

Authors

D H HULL

P J Beale

Affiliations

Soon will be listed here.

Abstract

Tobacco smoking delays healing of gastric ulcer and may influence duodenal ulceration. Seventy men, all cigarette smokers, were found to have duodenal ulceration at endoscopy. All were advised to stop smoking and received a three-month course of cimetidine. Endoscopy was repeated at three months (n = 63) and at six months (n = 56). At three months most (79%) patients showed ulcer healing and there was no difference between men who had and had not stopped smoking. At six months, however, a higher proportion (61% vs 28%, p less than 0.05) of smokers (n = 38) than ex-smokers (n = 18) had duodenal ulceration. This difference reflected a combination of increased ulcer persistence and ulcer relapse. Neither cimetidine nor cigarette smoking nor ulcer healing appeared substantially to affect duodenitis and fixed deformity. We conclude that continued cigarette smoking does not prevent the powerful duodenal ulcer healing effect of cimetidine but does predispose to an increased expectation of duodenal ulceration soon after cimetidine has been stopped.

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References

Lam S . Antrectomy and maximal acid output. Gastroenterology. 1980; 79(1):181-2. View

Ross A, Smith M, ANDERSON J, SMALL W . Late mortality after surgery for peptic ulcer. N Engl J Med. 1982; 307(9):519-22. DOI: 10.1056/NEJM198208263070902. View

Lee F, Fielding J, Costello F . Ranitidine compared with cimetidine in the short-term healing of duodenal ulcer. Postgrad Med J. 1983; 59(688):88-92. PMC: 2417403. DOI: 10.1136/pgmj.59.688.88. View

Korman M, Hansky J, Merrett A, Schmidt G . Ranitidine in duodenal ulcer: incidence of healing and effect of smoking. Dig Dis Sci. 1982; 27(8):712-5. DOI: 10.1007/BF01393766. View

Sontag S, Graham D, Belsito A, Weiss J, Farley A, Grunt R . Cimetidine, cigarette smoking, and recurrence of duodenal ulcer. N Engl J Med. 1984; 311(11):689-93. DOI: 10.1056/NEJM198409133111101. View

Gugler R, Rohner H, Kratochvil P, Brandstatter G, Schmitz H . Effect of smoking on duodenal ulcer healing with cimetidine and oxmetidine. Gut. 1982; 23(10):866-71. PMC: 1419832. DOI: 10.1136/gut.23.10.866. View

Sonnenberg A, Muller-Lissner S, Vogel E, Schmid P, Gonvers J, Peter P . Predictors of duodenal ulcer healing and relapse. Gastroenterology. 1981; 81(6):1061-7. View

Korman M, Shaw R, Hansky J, Schmidt G, Stern A . Influence of smoking on healing rate of duodenal ulcer in response to cimetidine or high-dose antacid. Gastroenterology. 1981; 80(6):1451-3. View

Frederiksen H, Matzen P, Madsen P, Kragelund E, KRAG E, Christiansen P . Spontaneous healing of duodenal ulcers. Scand J Gastroenterol. 1984; 19(3):417-21. View

10.

Lam S, Lam K, Lai C, Yeung C, Yam L, Wong W . Treatment of duodenal ulcer with antacid and sulpiride. A double-blind controlled study. Gastroenterology. 1979; 76(2):315-22. View

11.

Marks I, Wright J, Denyer M, Garisch J, LUCKE W . Comparison of sucralfate with cimetidine in the short-term treatment of chronic peptic ulcers. S Afr Med J. 1980; 57(15):567-73. View

12.

PETERSON W, Sturdevant R, FRANKL H, Richardson C, Isenberg J, Elashoff J . Healing of duodenal ulcer with an antacid regimen. N Engl J Med. 1977; 297(7):341-5. DOI: 10.1056/NEJM197708182970701. View

13.

Korman M, Hansky J, Eaves E, Schmidt G . Influence of cigarette smoking on healing and relapse in duodenal ulcer disease. Gastroenterology. 1983; 85(4):871-4. View

14.

Hetzel D, Korman M, Hansky J, Shearman D, Eaves E, Schmidt G . The influence of smoking on the healing of duodenal ulcer treated with oxmetidine or cimetidine. Aust N Z J Med. 1983; 13(6):587-90. DOI: 10.1111/j.1445-5994.1983.tb02609.x. View

15.

DOLL R, Peto R . Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J. 1976; 2(6051):1525-36. PMC: 1690096. DOI: 10.1136/bmj.2.6051.1525. View

16.

Bianchi Porro G, Petrillo M, Grossi K, Lazzaroni M . Smoking and duodenal ulcer. Gastroenterology. 1980; 79(1):180-1. View

17.

Lam S, Koo J . Accurate prediction of duodenal-ulcer healing rate by discriminant analysis. Gastroenterology. 1983; 85(2):403-12. View

18.

Bardhan K . Refractory duodenal ulcer. Gut. 1984; 25(7):711-7. PMC: 1432597. DOI: 10.1136/gut.25.7.711. View

19.

DOLL R, JONES F, PYGOTT F . Effect of smoking on the production and maintenance of gastric and duodenal ulcers. Lancet. 1958; 1(7022):657-62. DOI: 10.1016/s0140-6736(58)91083-3. View

20.

Young G, St John D, Coventry D . Treatment of duodenal ulcer with carbenoxolone sodium: a double-masked endoscopic trial. Med J Aust. 1979; 1(1):2-5. DOI: 10.5694/j.1326-5377.1979.tb111930.x. View