The Inhibition of Protein-lysine 6-oxidase by Various Lathyrogens. Evidence for Two Different Mechanisms

Overview

Journal Biochem J

Specialty Biochemistry

Date 1985 Nov 15

PMID 4084235

Citations 5

Authors

C I LEVENE

M J Carrington

Affiliations

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Abstract

Lathyrogens decrease collagen and elastin cross-linking by inhibiting lysine oxidase. The lathyrogens isoniazid and semicarbazide decrease liver pyridoxal phosphate and are teratogenic; all their effects are reversed by pyridoxal. beta-Aminopropionitrile, another lathyrogen, does not affect liver pyridoxal phosphate, and its lathyrogenic and teratogenic effects are not reversed by pyridoxal. Time courses of these effects differ greatly, suggesting enzyme inhibition by different mechanisms.

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