1-hydroxypyrene in Human Urine After Exposure to Coal Tar and a Coal Tar Derived Product

Overview

Journal Int Arch Occup Environ Health

Specialty Environmental Health

Date 1985 Jan 1

PMID 4077281

Citations 22

Authors

F J Jongeneelen

R B Anzion

C M Leijdekkers

R P Bos

P T Henderson

Affiliations

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Abstract

A method for isolating 1-hydroxypyrene from urine is described. The presence of 1-hydroxypyrene in urine was identified by fluorescence excitation and emission scanning after HPLC-separation. 1-Hydroxypyrene could be detected in the urine of rats following oral administration of as little as 0.5 microgram pyrene. The dose-dependence of 1-hydroxypyrene in urine was evident after a wide range of pyrene dosing. After therapeutical coal tar treatment of dermatological patients the enhanced excretion of 1-hydroxypyrene was highly significant. Employees of a creosote impregnating plant showed an excretion pattern of 1-hydroxypyrene which could be related to their work. 1-Hydroxypyrene in urine of non-exposed people was very low, but detectable. It is suggested that the method reported is suitable for the assessment of uptake of man to pyrene, a compound that is commonly present in work environments which are associated with pollution of polycyclic aromatic hydrocarbons.

Citing Articles

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Occupational exposure to polycyclic aromatic hydrocarbons: relations between atmospheric mixtures, urinary metabolites and sampling times.

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