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A Comparison of the Cardiovascular Effects of (+)-sotalol and (+/-)-sotalol Following Intravenous Administration in Normal Volunteers

Overview
Journal Br J Clin Pharmacol
Specialty Pharmacology
Date 1985 Nov 1
PMID 4074623
Citations 6
Authors
G D Johnston
M B Finch
J A McNEILL
R G Shanks
Affiliations
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Abstract

In a placebo controlled open study in six healthy male volunteers (+)-sotalol in the dose range 0.125 mg kg-1-2.0 mg kg-1 intravenously, was found to have little or no beta-adrenoceptor blocking activity in comparison to the racemic mixture (+/-)-sotalol. The repolarization effects of (+)- and (+/-)-sotalol on the QTc interval however were comparable over the same dose range. The beta-adrenoceptor blocking activity and repolarization effects of sotalol appear to be unrelated.

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