Contrasts Between Pindolol and Propranolol Concentration-response Relationships

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1985 Oct 1

PMID 4074610

Citations 2

Authors

S G Carruthers

W L PACHA

W H Aellig

Affiliations

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Abstract

The plasma concentration-response relationships of oral and intravenous pindolol and propranolol have been studied in a group of eight healthy male subjects who received each dosage form in a randomized single-blind cross-over manner. Despite similar elimination half-lives, the duration of action of pindolol was longer than that of propranolol. This longer duration of action was associated with a flatter concentration-response curve for pindolol and may be related to the partial agonist activity of pindolol. Propranolol concentration-response curves were dependent on the route of drug administration whereas pindolol curves were similar following oral and intravenous routes of administration.

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