Brain-derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies

Overview

Journal Science

Specialty Science

Date 1985 Dec 20

PMID 4071057

Citations 55

Authors

G Gimenez-Gallego

J Rodkey

C Bennett

J DiSalvo

K Thomas

Affiliations

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Abstract

Bovine brain-derived acidic fibroblast growth factor (aFGF) is a protein mitogen originally identified in partially purified preparations of whole brain. The protein was purified to homogeneity and shown to be a potent vascular endothelial cell mitogen in culture and angiogenic substance in vivo. The homology of aFGF to human interleukin-1 beta was inferred from partial sequence data. The complete amino acid sequence of aFGF has now been determined and observed to be similar to both basic FGF and interleukin-1's. A neuropeptide-like sequence, flanked by basic dipeptides, was observed within the aFGF sequence.

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