Macromolecular Permeability of the Tight Junction of the Human Nasal Mucosa

Overview

Journal Rhinology

Specialty Otorhinolaryngology

Date 1985 Sep 1

PMID 4059806

Citations 10

Authors

M Inagaki

Y Sakakura

H Itoh

K Ukai

Y Miyoshi

Affiliations

Soon will be listed here.

Abstract

Using HRP as a cytochemical tracer, we investigated the tight junctional permeability of the human nasal mucosa in the early stage of its transportation. We found that the tight junction becomes "leaky" in the inflammatory and in the allergic conditions. Connection of goblet-goblet and goblet-ciliated cells were weaker than that of ciliated-ciliated cells. All epithelial tight junctions seemed to be loose in cases of allergic rhinitis.

Citing Articles

The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 1-Establishing a Nasal In Vitro Model for Drug Delivery Testing Based on a Novel Cell Line.

Bendas S, Koch E, Nehlsen K, May T, Dietzel A, Reichl S Pharmaceutics. 2023; 15(9).

PMID: 37765214 PMC: 10536430. DOI: 10.3390/pharmaceutics15092245.

Oxytocin delivered nasally or intraperitoneally reaches the brain and plasma of normal and oxytocin knockout mice.

Smith A, Korgan A, Young W Pharmacol Res. 2019; 146:104324.

PMID: 31238093 PMC: 6679720. DOI: 10.1016/j.phrs.2019.104324.

Impaired virus replication and decreased innate immune responses to viral infections in nasal epithelial cells from patients with allergic rhinitis.

Globinska A, Pawelczyk M, Piechota-Polanczyk A, Olszewska-Ziaber A, Moskwa S, Mikolajczyk A Clin Exp Immunol. 2016; 187(1):100-112.

PMID: 27667736 PMC: 5167059. DOI: 10.1111/cei.12869.

Airway permeability.

Persson C, Andersson M, Greiff L, Svensson C, Erjefalt J, Sundler F Clin Exp Allergy. 1995; 25(9):807-14.

PMID: 8564718 PMC: 7162050. DOI: 10.1111/j.1365-2222.1995.tb00022.x.

Effect of intranasal histamine on nasal mucosal blood flow and the antidiuretic activity of desmopressin.

Olanoff L, Titus C, SHEA M, Gibson R, BROOKS C J Clin Invest. 1987; 80(3):890-5.

PMID: 3624491 PMC: 442317. DOI: 10.1172/JCI113148.