Opiate-induced Inhibition of the Visceral Distension Reflex by Peripheral and Central Mechanisms

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1985 Sep 1

PMID 4058597

Citations 7

Authors

S J Clark

T W Smith

Affiliations

Soon will be listed here.

Abstract

Distension of the proximal ileum by elevation of the intraluminal pressure, caused a transient, reflex fall in blood pressure of urethane-anaesthetised rats. The threshold intraluminal pressure required to evoke a reflex response was increased by codeine, but not by the quaternary opiate agonist N-methylmorphine. The magnitude of the reflex hypotension was decreased by codeine, morphine and N-methylmorphine. The quaternary opiate antagonist N-methylnalorphine reduced the effects of N-methylmorphine, but not those of codeine or morphine. Codeine-induced inhibition of reflex depressor responses was reduced by pretreatment with naloxone. Bilateral vagotomy caused a significant decrease in effects of codeine on the threshold, but not the magnitude, of reflex depressor responses. Furthermore N-methylnalorphine antagonised both codeine- and morphine-induced inhibition of depressor responses following transsection of the vagus nerves. Effects of opiates on the threshold for the reflex appear to be centrally mediated and to require an intact vagal innervation. The magnitude of depressor responses is largely independent of vagal innervation and may be influenced by opiates acting via peripheral mechanisms.

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References

Lorenzetti B, Ferreira S . The analgesic effect of quaternary analogues of morphine and nalorphine. Braz J Med Biol Res. 1982; 15(4-5):285-90. View

Smith T, Buchan P, Parsons D, Wilkinson S . Peripheral antinociceptive effects of N-methyl morphine. Life Sci. 1982; 31(12-13):1205-8. DOI: 10.1016/0024-3205(82)90343-5. View

Tavani A, Bianchi G, Manara L . Morphine no longer blocks gastrointestinal transit but retains antinociceptive action in diallylnormorphine-pretreated rats. Eur J Pharmacol. 1979; 59(1-2):151-4. DOI: 10.1016/0014-2999(79)90039-6. View

Ferreira S, Nakamura M . III - Prostaglandin hyperalgesia: relevance of the peripheral effect for the analgesic action of opioid-antagonists. Prostaglandins. 1979; 18(2):201-8. DOI: 10.1016/0090-6980(79)90105-9. View

Dashwood M, Kiang J, Wei E . An etorphine-evoked vagal reflex in rats is inhibited by naloxone, N-methylnaloxone, and SMS 201-995. Arch Int Pharmacodyn Ther. 1983; 266(1):77-82. View

Sapru H, Willette R, Krieger A . Stimulation of pulmonary J receptors by an enkephalin-analog. J Pharmacol Exp Ther. 1981; 217(1):228-34. View

Bianchi G, Fiocchi R, Peracchia F, Petrillo P, Tavani A, Manara L . The peripheral narcotic antagonist N-allyl levallorphan-bromide (CM 32191) selectively prevents morphine antipropulsive action and buprenorphine in-vivo binding in the rat intestine. J Pharm Pharmacol. 1984; 36(5):326-30. DOI: 10.1111/j.2042-7158.1984.tb04384.x. View

Giles T, Sander G, Merz H . Quaternary opiate antagonists lower blood pressure and inhibit leucine-enkephalin responses. Eur J Pharmacol. 1983; 95(3-4):247-52. DOI: 10.1016/0014-2999(83)90641-6. View

Fennessy M, Rattray J . Cardiovascular effects of intravenous morphine in the anaesthetized rat. Eur J Pharmacol. 1971; 14(1):1-8. DOI: 10.1016/0014-2999(71)90116-6. View

10.

Lembeck F, Skofitsch G . Visceral pain reflex after pretreatment with capsaicin and morphine. Naunyn Schmiedebergs Arch Pharmacol. 1982; 321(2):116-22. DOI: 10.1007/BF00518478. View

11.

Foster R, JENDEN D, LOMAX P . A comparison of the pharmacologic effects of morphine and N-methyl morphine. J Pharmacol Exp Ther. 1967; 157(1):185-95. View

12.

KOSTERLITZ H, Waterfield A . In vitro models in the study of structure-activity relationships of narcotic analgesics. Annu Rev Pharmacol. 1975; 15:29-47. DOI: 10.1146/annurev.pa.15.040175.000333. View

13.

Russell J, Bass P, Goldberg L, Schuster C, Merz H . Antagonism of gut, but not central effects of morphine with quaternary narcotic antagonists. Eur J Pharmacol. 1982; 78(3):255-61. DOI: 10.1016/0014-2999(82)90026-7. View

14.

Brasch H, ZETLER G . Caerulein and morphine in a model of visceral pain. Effects on the hypotensive response to renal pelvis distension in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1982; 319(2):161-7. DOI: 10.1007/BF00503931. View

15.

Clarke G, Davison J . Proceedings: Vagal afferent nerve endings in the gastric antral mucosa of the rat. J Physiol. 1974; 239(1):41P-42P. View

16.

KADLEC O, Horacek J . Inhibition of peristaltic activity in the guinea-pig ileum by specific stress stimulus; its reversal by naloxone and indomethacin. Life Sci. 1980; 27(17):1557-62. DOI: 10.1016/0024-3205(80)90564-0. View

17.

Ferreira S, Nakamura M . II - Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. Prostaglandins. 1979; 18(2):191-200. DOI: 10.1016/0090-6980(79)90104-7. View

18.

Iggo A . Gastro-intestinal tension receptors with unmyelinated afferent fibres in the vagus of the cat. Q J Exp Physiol Cogn Med Sci. 1957; 42(1):130-43. DOI: 10.1113/expphysiol.1957.sp001228. View