Biliary Squalene Levels in Hepatobiliary Disease

Overview

Journal Gastroenterol Jpn

Specialty Gastroenterology

Date 1985 Aug 1

PMID 4054510

Authors

Y Nosaka

Y Yamanishi

C Hirayama

Affiliations

Soon will be listed here.

Abstract

Following overnight fasting, biliary levels of squalene, bile salts, cholesterol and phospholipid were estimated using human bile obtained with a duodenal double lumen catheter after administration of caerulein. While the squalene level in B-bile was 6.86 microM in the control group, it fell significantly in patients with parenchymal liver diseases, especially liver cirrhosis. There was no significant change in the level in patients with cholelithiasis. Biliary squalene concentration showed a significant correlation with concentrations of bile salts, cholesterol and phospholipid. These results substantiate the possibility that the biliary squalene level reflects sterol metabolism in the liver.

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