Mitochondrial Biogenesis: Inhibitors of Mitochondrial Protein Synthesis

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 1977 Feb 4

PMID 404520

Citations 3

Authors

D Wilkie

Affiliations

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Abstract

The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes in the cellular membranes and mitotic arrest. The data are discussed.

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