Comparison of Human Lactoferrins from Milk and Neutrophilic Leucocytes. Relative Molecular Mass, Isoelectric Point, Iron-binding Properties and Uptake by the Liver

Overview

Journal Biochem J

Specialty Biochemistry

Date 1985 Jul 15

PMID 4038272

Citations 15

Authors

N Moguilevsky

L A Retegui

P L Masson

Affiliations

Soon will be listed here.

Abstract

Human lactoferrins isolated from neutrophilic leucocytes and milk by CM-Sephadex chromatography were similar in Mr (76000) and pI (8.7). Upon acidification, both proteins released their two Fe3+ ions/molecule in a similar biphasic way. Both proteins intravenously injected into mice were cleared from plasma at the same rate. The maximal uptakes by the liver, which occurred 5 min after injection, were inhibited to the same extent by milk lactoferrin used as a competitor.

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