New Antitumor Antibiotics, FR-900405 and FR-900406. II. Production, Isolation, Characterization and Antitumor Activity

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 1985 Jul 1

PMID 4030499

Citations 2

Authors

S Kiyoto

M Nishikawa

H Terano

M Kohsaka

H Aoki

H Imanaka

Y Kawai

I Uchida

M Hashimoto

Affiliations

Soon will be listed here.

Abstract

The new antitumor antibiotics, FR-900405 and FR-900406, were isolated from the culture broth of Actinomadura pulveracea sp. nov. No. 6049. These compounds which contain sulfur in the molecule, represent a novel class of antitumor agents. FR-900405 and FR-900406 are highly active in mice against experimental tumors and exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi.

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