Experimental Toxemia of Pregnancy in the Monkey, with a Preliminary Report on Renin and Aldosterone

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1977 Mar 1

PMID 402816

Citations 10

Authors

M M Abitbol

M B Ober

G R Gallo

S G DRISCOLL

C L PIRANI

Affiliations

Soon will be listed here.

Abstract

Experimental toxemia of pregnancy was induced in 8 pregnant monkeys (Macacamulatta) by reducing the abdomiinal aorta to one-third of its original diameter during the last month of gestation. It was characterized by hypertension and proteinuria. In the kidney, light and electron microscopy and immunofluorescence revealed findings similar to those in human toxemia. Focal necrosis in the liver and diffuse hemorrhagic infarctions in the placenta were also observed. Plasma renin activity and aldosterone levels, as determined in blood from the uterine vein, were elevated. None of these changes were found in 4 control animals.

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