Neurotensin Depolarizes Substantia Nigra Dopamine Neurones

Overview

Journal Brain Res

Specialty Neurology

Date 1985 Jul 8

PMID 4027584

Citations 18

Authors

R D Pinnock

Affiliations

Soon will be listed here.

Abstract

Neurotensin and the C-terminal 8-13 amino acid fragment were found to excite substantia nigra compacta dopamine neurones in vitro in a dose-dependent manner. The N-terminal 1-8 amino acid fragment was not active at the concentrations used. Desensitization was not observed. Intracellular recordings from the neurones responding to dopamine showed neurotensin-depolarized cells with an increase or no change in input resistance. These actions persisted in zero calcium, 8 mM magnesium artificial CSF suggesting a post-synaptic action.

Citing Articles

Diverse roles of neurotensin agonists in the central nervous system.

Boules M, Li Z, Smith K, Fredrickson P, Richelson E Front Endocrinol (Lausanne). 2013; 4:36.

PMID: 23526754 PMC: 3605594. DOI: 10.3389/fendo.2013.00036.

The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia.

Smith K, Boules M, Williams K, Fauq A, Richelson E Behav Brain Res. 2011; 224(2):344-9.

PMID: 21718721 PMC: 3159772. DOI: 10.1016/j.bbr.2011.06.014.

The role of neurotensin in central nervous system pathophysiology: what is the evidence?.

St-Gelais F, Jomphe C, Trudeau L J Psychiatry Neurosci. 2006; 31(4):229-45.

PMID: 16862241 PMC: 1488904.

Role of calcium in neurotensin-evoked enhancement in firing in mesencephalic dopamine neurons.

St-Gelais F, Legault M, Bourque M, Rompre P, Trudeau L J Neurosci. 2004; 24(10):2566-74.

PMID: 15014132 PMC: 6729478. DOI: 10.1523/JNEUROSCI.5376-03.2004.

Neurotensin effect on Na+, K+-ATPase is CNS area- and membrane-dependent and involves high affinity NT1 receptor.

Lopez Ordieres M, Rodriguez de Lores Arnaiz G Neurochem Res. 2003; 27(11):1555-61.

PMID: 12512960 DOI: 10.1023/a:1021612825025.