Angiogenesis: a Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia

Overview

Journal Science

Specialty Science

Date 1977 Mar 4

PMID 402692

Citations 29

Authors

S S Brem

P M Gullino

D Medina

Affiliations

Soon will be listed here.

Abstract

Mouse mammary papillomas elicit new formation of vessels when transplanted onto the rabbit iris. This angiogenic capacity is a property of carcinomas but not of the resting mammary gland. In mouse papillary hyperplasias, however, this property appears much earlier than any morphological or clinical sign of carcinoma. A test for angiogenic capacity may reveal a step in the progression toward clinical malignancy and thus could be used to screen for neoplastic potential of hyperplastic epithelium in biopsy tissues.

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