Alpha 2.0
Login Register
» Articles » PMID: 4026285

TDP-1, a Toxic Component Causing Tibial Dyschondroplasia in Broiler Chickens, and Trichothecenes from Fusarium Roseum 'Graminearum'

Overview
Journal Appl Environ Microbiol
Specialties Environmental Health
Microbiology
Date 1985 Jul 1
PMID 4026285
Citations 14
Authors
Y W Lee
C J Mirocha
D J Shroeder
M M Walser
Affiliations
Soon will be listed here.
Abstract

Fusarium roseum 'Graminearum' was isolated from overwintered oats in Alaska and was tested for its ability to cause tibial dyschondroplasia (TDP) in broiler chickens. The water-soluble fraction was tested and found to cause TDP. In addition, diacetoxyscirpenol and 7-hydroxydiacetoxyscirpenol were identified in the acetonitrile fraction of the extracts and caused mild mouth lesions in chickens. Six major water-soluble components were purified by thin-layer chromatography and tested for toxicity to chick embryos. One of the six components, called TDP-1, was found to be lethal to chick embryos. There was a 100% incidence of TDP in chickens fed a diet containing 75 ppm (wt/wt) of pure TDP-1, thus establishing the cause and effect relationship between TDP and TDP-1. Analyses by thin-layer chromatography and mass spectrometry revealed that TDP-1 is polar and ninhydrin positive, exhibits fluorescence with UV irradiation, and is a nitrogen-containing component with an empirical formula of C15H20N2O4.

Citing Articles

TNBC Therapeutics Based on Combination of Fusarochromanone with EGFR Inhibitors.

Carroll N, Youngblood R, Smith A, Dragoi A, Salvatore B, Mahdavian E Biomedicines. 2022; 10(11).

PMID: 36428475 PMC: 9687139. DOI: 10.3390/biomedicines10112906.

Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5.

Gu Y, Barzegar M, Chen X, Wu Y, Shang C, Mahdavian E Oncotarget. 2015; 6(39):42322-33.

PMID: 26517353 PMC: 4747228. DOI: 10.18632/oncotarget.5996.

Fusarochromanone induces G1 cell cycle arrest and apoptosis in COS7 and HEK293 cells.

Gu Y, Chen X, Shang C, Singh K, Barzegar M, Mahdavian E PLoS One. 2014; 9(11):e112641.

PMID: 25384025 PMC: 4226581. DOI: 10.1371/journal.pone.0112641.

Biological activities of fusarochromanone: a potent anti-cancer agent.

Mahdavian E, Palyok P, Adelmund S, Williams-Hart T, Furmanski B, Kim Y BMC Res Notes. 2014; 7:601.

PMID: 25187308 PMC: 4168212. DOI: 10.1186/1756-0500-7-601.

A survey of the occurrence of Fusarium mycotoxins (trichothecenes, zearalenone, and fusarochromanone) in corn and wheat samples from Shaanxi and Shanxi Provinces, China.

Luo Y, Yoshizawa T, Yang J, Zhang S, Zhang B Mycotoxin Res. 2013; 8(2):85-91.

PMID: 23606004 DOI: 10.1007/BF03192221.

References
1.
Leach Jr R, Nesheim M . Further studies on tibial dyschondroplasia (cartilage abnormality) in young chicks. J Nutr. 1972; 102(12):1673-80. DOI: 10.1093/jn/102.12.1673. View
2.
Hsu I, Smalley E, STRONG F, RIBELIN W . Identification of T-2 toxin in moldy corn associated with a lethal toxicosis in dairy cattle. Appl Microbiol. 1972; 24(5):684-90. PMC: 380645. DOI: 10.1128/am.24.5.684-690.1972. View
3.
Sharby T, Templeton G, Beasley J, Stephenson E . Toxicity resulting from feeding experimentally molded corn to broiler chicks. Poult Sci. 1973; 52(3):1007-14. DOI: 10.3382/ps.0521007. View
4.
Itakura C, Goto M, Fujiwara Y . Tibial dyschondroplasia in broiler chickens in Japan. Nihon Juigaku Zasshi. 1973; 35(4):289-97. DOI: 10.1292/jvms1939.35.289. View
5.
Puls R, GREENWAY J . Fusariotoxicosis from barley in British Columbia. II. Analysis and toxicity of syspected barley. Can J Comp Med. 1976; 40(1):16-9. PMC: 1277513. View