Hypothalamic Thermosensitivity in Capsaicin-desensitized Rats

Overview

Journal J Physiol

Specialty Physiology

Date 1985 Jun 1

PMID 4020699

Citations 2

Authors

S G Shimada

J T Stitt

Affiliations

Soon will be listed here.

Abstract

In rats, we tested the hypothesis that capsaicin desensitization reduces hypothalamic warm thermosensitivity. We locally heated and cooled the hypothalamus using water-perfused thermodes while observing thermoregulatory variables. In untreated rats, a small dose of capsaicin had profound effects on thermoregulation. However, desensitizing rats to capsaicin had no effect on hypothalamic thermosensitivity for metabolic rate or changes in body temperature due to displacements of hypothalamic temperature. Contrary to current opinion, we conclude that capsaicin desensitization does not alter hypothalamic thermosensitivity to warm or cold.

Citing Articles

Hypoxia reduces the hypothalamic thermogenic threshold and thermosensitivity.

Tattersall G, Milsom W J Physiol. 2009; 587(Pt 21):5259-74.

PMID: 19770191 PMC: 2790263. DOI: 10.1113/jphysiol.2009.175828.

A study of the mechanism of action of the mild analgesic dipyrone.

Shimada S, Otterness I, Stitt J Agents Actions. 1994; 41(3-4):188-92.

PMID: 7942328 DOI: 10.1007/BF02001915.

References

Szolcsanyi J, Joo F, JANCSO-GABOR A . Mitochondrial changes in preoptic neurons after capsaicin desensitization of the hypothalamic thermodetectors in rats. Nature. 1971; 229(5280):116-7. DOI: 10.1038/229116a0. View

COLERIDGE H, COLERIDGE J, Kidd C . ROLE OF THE PULMONARY ARTERIAL BARORECEPTORS IN THE EFFECTS PRODUCED BY CAPSAICIN IN THE DOG. J Physiol. 1964; 170:272-85. PMC: 1368814. DOI: 10.1113/jphysiol.1964.sp007330. View

JANCSO-GABOR A, Szolcsanyi J, JANCSO N . Stimulation and desensitization of the hypothalamic heat-sensitive structures by capsaicin in rats. J Physiol. 1970; 208(2):449-59. PMC: 1348759. DOI: 10.1113/jphysiol.1970.sp009130. View

Webb-Peploe M, Brender D, SHEPHERD J . Vascular responses to stimulation of receptors in muscle by capsaicin. Am J Physiol. 1972; 222(1):189-95. DOI: 10.1152/ajplegacy.1972.222.1.189. View

Toda N, Usui H, Nishino N, Fujiwara M . Cardiovascular effects of capsaicin in dogs and rabbits. J Pharmacol Exp Ther. 1972; 181(3):512-21. View

Stitt J . The regulation of respiratory evaporative heat loss in the rabbit. J Physiol. 1976; 258(1):157-71. PMC: 1308965. DOI: 10.1113/jphysiol.1976.sp011412. View

Cabanac M, POIRIER L . The effect of capsaïcin on temperature regulation of the rat. Pflugers Arch. 1976; 366(2-3):217-21. DOI: 10.1007/BF00585881. View

Jancso G, KIRALY E, JANCSO-GABOR A . Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature. 1977; 270(5639):741-3. DOI: 10.1038/270741a0. View

Gamse R, Molnar A, Lembeck F . Substance P release from spinal cord slices by capsaicin. Life Sci. 1979; 25(7):629-36. DOI: 10.1016/0024-3205(79)90558-7. View

10.

Hori T, Shinohara K . Hypothalamic thermo-responsive neurones in the new-born rat. J Physiol. 1979; 294:541-60. PMC: 1280572. DOI: 10.1113/jphysiol.1979.sp012945. View

11.

Virus R, Gebhart G . Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin. Life Sci. 1979; 25(15):1273-83. DOI: 10.1016/0024-3205(79)90392-8. View

12.

Gamse R, Holzer P, Lembeck F . Decrease of substance P in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin. Br J Pharmacol. 1980; 68(2):207-13. PMC: 2043922. DOI: 10.1111/j.1476-5381.1980.tb10409.x. View

13.

Hori T, Nakashima T, Hori N, Kiyohara T . Thermo-sensitive neurons in hypothalamic tissue slices in vitro. Brain Res. 1980; 186(1):203-7. DOI: 10.1016/0006-8993(80)90266-8. View

14.

. The effect of ambient temperature on rectal temperature, food intake and short term body weight in the capsaicin desensitized rat. Pflugers Arch. 1981; 389(2):171-4. DOI: 10.1007/BF00582109. View

15.

Hori T . Thermosensitivity of preoptic and anterior hypothalamic neurons in the capsaicin-desensitized rat. Pflugers Arch. 1981; 389(3):297-9. DOI: 10.1007/BF00584793. View

16.

Hori T, Tsuzuki S . Thermoregulation in adult rats which have been treated with capsaicin as neonates. Pflugers Arch. 1981; 390(3):219-23. DOI: 10.1007/BF00658265. View

17.

Nagy J, Hunt S, Iversen L, Emson P . Biochemical and anatomical observations on the degeneration of peptide-containing primary afferent neurons after neonatal capsaicin. Neuroscience. 1981; 6(10):1923-34. DOI: 10.1016/0306-4522(81)90032-4. View

18.

Saria A, Skofitsch G, Lembeck F . Distribution of capsaicin in rat tissues after systemic administration. J Pharm Pharmacol. 1982; 34(4):273-5. DOI: 10.1111/j.2042-7158.1982.tb04245.x. View

19.

Donnerer J, Lembeck F . Analysis of the effects of intravenously injected capsaicin in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1982; 320(1):54-7. DOI: 10.1007/BF00499072. View

20.

Szikszay M, Obal Jr F, OBAL F . Dose-response relationships in the thermoregulatory effects of capsaicin. Naunyn Schmiedebergs Arch Pharmacol. 1982; 320(2):97-100. DOI: 10.1007/BF00506307. View