» Articles » PMID: 4018736

Increased Serum Levels of Hyaluronate in Liver Disease

Overview
Journal Hepatology
Specialty Gastroenterology
Date 1985 Jul 1
PMID 4018736
Citations 30
Authors
Affiliations
Soon will be listed here.
Abstract

Recent animal studies show that endothelial cells in liver sinusoids are the main site for removal of sodium hyaluronate from the circulation. Few data with respect to hyaluronate metabolism are available in man. Serum hyaluronate levels were measured in 119 patients with liver disease by a sensitive assay. The hyaluronate level was significantly increased in liver cirrhosis, in comparison with healthy controls and with patients with noncirrhotic liver disease. The results suggest a role for the human liver in elimination of hyaluronate from circulation. Quantification of serum hyaluronate may be a useful test of liver endothelial cell function.

Citing Articles

The diagnostic utility of glycosaminoglycans (GAGs) in the early detection of cancer: a systematic review.

Douglah S, Khalil R, Kanaan R, Almeqbaali M, Abdelmonem N, Abdelmessih M PeerJ. 2024; 12:e18486.

PMID: 39583112 PMC: 11586047. DOI: 10.7717/peerj.18486.


Revisiting Circulating Extracellular Matrix Fragments as Disease Markers in Myelofibrosis and Related Neoplasms.

Hasselbalch H, Junker P, Skov V, Kjaer L, Knudsen T, Larsen M Cancers (Basel). 2023; 15(17).

PMID: 37686599 PMC: 10486581. DOI: 10.3390/cancers15174323.


'Two-faces' of hyaluronan, a dynamic barometer of disease progression in tumor microenvironment.

Liu Y, Li L, Wang L, Lu L, Li Y, Huang G Discov Oncol. 2023; 14(1):11.

PMID: 36698043 PMC: 9877274. DOI: 10.1007/s12672-023-00618-1.


The Scavenger Function of Liver Sinusoidal Endothelial Cells in Health and Disease.

Bhandari S, Larsen A, McCourt P, Smedsrod B, Sorensen K Front Physiol. 2021; 12:757469.

PMID: 34707514 PMC: 8542980. DOI: 10.3389/fphys.2021.757469.


Liver impairment in critical illness and sepsis: the dawn of new biomarkers?.

Kluge M, Tacke F Ann Transl Med. 2020; 7(Suppl 8):S258.

PMID: 32015977 PMC: 6976419. DOI: 10.21037/atm.2019.12.79.