High-performance Liquid Chromatographic Assay for Simultaneous Estimation of Aminoglutethimide and Acetylaminoglutethimide in Biological Fluids

Overview

Journal Cancer Chemother Pharmacol

Specialty Oncology

Date 1985 Jan 1

PMID 4017167

Citations 4

Authors

A M Adam

I D Bradbrook

H J Rogers

Affiliations

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Abstract

A simple rapid high-performance liquid chromatographic assay for simultaneous estimation of aminoglutethimide and its acetylated metabolite acetylamidoglutethimide in plasma, saliva, and urine is described. This assay is suitable for pharmacokinetic studies in normal subjects and patients receiving other medication in addition to aminoglutethimide.

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