The Monensin-mediated Transport of Sodium Ions Through Phospholipid Bilayers Studied by 23Na-NMR Spectroscopy

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1985 Jul 25

PMID 4016108

Citations 11

Authors

F G Riddell

M K Hayer

Affiliations

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Abstract

The monensin-mediated transport of sodium ions through the walls of large unilamellar vesicles of egg phosphatidylcholine was studied using 23Na-NMR and aqueous shift reagents. The transport is dynamic on the NMR time-scale and is strictly first order in monensin over the concentration ranges studied indicating that transport occurs by a 1:1 Na+-ionophore complex. Transport appears to be inhibited by increasing concentrations of Na+.

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