Cardiac Biomarkers Predict Low Right Ventricle Performance in Neonatal Encephalopathy

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2025 Mar 16

PMID 40089578

Authors

Shiran Sara Moore

Anie Lapointe

Emmanouil Rampakakis

Jessica Simoneau

Pierre Elias

Alishia Poccia

Asim Al Balushi

Adel Schwertani

Pia Wintermark

Gabriel Altit

Affiliations

Soon will be listed here.

Abstract

Objective: Study the association between cardiac biomarkers and echocardiography parameters of ventricular performance in neonates with neonatal encephalopathy (NE).

Methods: Prospective observational study (2016-2021) of neonates undergoing therapeutic hypothermia (TH). Neonates with brain injury had repeated echocardiography and biomarkers measurements on day of life (DOL) 2, 3, 4, and 10. Pearson correlation and generalized linear mixed effect models were used to account for repeated measurements. Receiver operating characteristic curves were constructed to assess sensitivity/specificity.

Results: 56 neonates had 128 measurements. Creatine Kinase (CK) and cardiac troponin-I (CTn-I) were associated with right ventricular (RV) function. A CK of 1961 U/L and a CTn-I of 91 ng/L identified low Tricuspid Annular Plane Systolic Excursion (<7 mm) with sensitivities of 93% and 79%, and specificities of 55% and 74%, respectively.

Conclusions: Elevated CK and CTn-I were associated with decreased RV performance. Trending these markers can be used to suspect altered RV function and may flag optimal timing for evaluation(s) by echocardiography during TH.

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