Global Burden of Substance Use Disorders Among Adolescents During 1990-2021 and a Forecast for 2022-2030: an Analysis for the Global Burden of Disease 2021

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2025 Mar 15

PMID 40087641

Authors

Chengchao Yu

Jianhua Chen

Affiliations

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Abstract

Background: Despite the increasing attention paid to adolescents with substance use disorders (SUD), the financial investment does not appear to align with the escalating demand for its prevention and treatment services. This study aims to provide comprehensive and up-to-date estimates of the burden of SUD among adolescents globally, regionally, and nationally over the last 32 years.

Methods: Utilizing data from the Global Burden of Disease, Injuries, and Risk Factors Study 2021, we concentrated on adolescents aged 10 to 24 years with SUD. We conducted a Bayesian age-period-cohort analysis and Nordpred model that encompasses age-standardized prevalence rates (ASPR), age-standardized incidence rates (ASIR), disability-adjusted life years (DALYs) rates, and estimated annual percentage change (EAPC) across various demographic factors, including regions, age groups, gender, and socio-demographic index (SDI), covering the period from 1990 to 2021.

Results: From 1990 to 2021, there was a significant decrease in the burden of adolescent SUD (EAPC = -1.17, 95%CI: -1.29 to -1.05). However, tremendously increasing trends of rate of DALYs were observed in high SDI regions (EAPC = 1.21, 95%CI: 1.11 to 1.32). Substantially increasing trend of burden attributable to adolescent SUD was detected in the United States of America (EAPC = 1.78, 95%CI: 1.64 to 1.92). Mongolia exhibited significantly increasing trend of ASPR (EAPC = 1.33, 95%CI: 1.10 to 1.56) and ASIR (EAPC = 1.21, 95%CI: 1.02 to 1.39). By 2030, the age-standardized DALYs rate of global adolescent SUD will decline from 88.49 to 79.27 per 100,000 individuals.

Conclusions: The burden of adolescent SUD shows diversity among SDI regions and countries. It ought to set a series of strict policies for adolescent substance control and precise financial management in prevention programs.

References

Beyers J, Toumbourou J, Catalano R, Arthur M, Hawkins J . A cross-national comparison of risk and protective factors for adolescent substance use: the United States and Australia. J Adolesc Health. 2004; 35(1):3-16. DOI: 10.1016/j.jadohealth.2003.08.015. View

Castaldelli-Maia J, Wang Y, Brunoni A, Faro A, Guimaraes R, Lucchetti G . Burden of disease due to amphetamines, cannabis, cocaine, and opioid use disorders in South America, 1990-2019: a systematic analysis of the Global Burden of Disease Study 2019. Lancet Psychiatry. 2023; 10(2):85-97. PMC: 9870787. DOI: 10.1016/S2215-0366(22)00339-X. View

Compton W, Jones C, Baldwin G, Harding F, Blanco C, Wargo E . Targeting Youth to Prevent Later Substance Use Disorder: An Underutilized Response to the US Opioid Crisis. Am J Public Health. 2019; 109(S3):S185-S189. PMC: 6595524. DOI: 10.2105/AJPH.2019.305020. View

Griffin K, Botvin G . Evidence-based interventions for preventing substance use disorders in adolescents. Child Adolesc Psychiatr Clin N Am. 2010; 19(3):505-26. PMC: 2916744. DOI: 10.1016/j.chc.2010.03.005. View

Jordan C, Andersen S . Sensitive periods of substance abuse: Early risk for the transition to dependence. Dev Cogn Neurosci. 2016; 25:29-44. PMC: 5410194. DOI: 10.1016/j.dcn.2016.10.004. View

Jurgens V, Ess S, Cerny T, Vounatsou P . A Bayesian generalized age-period-cohort power model for cancer projections. Stat Med. 2014; 33(26):4627-36. DOI: 10.1002/sim.6248. View

Lee B, Zhao W, Yang K, Ahn Y, Perry B . Systematic Evaluation of State Policy Interventions Targeting the US Opioid Epidemic, 2007-2018. JAMA Netw Open. 2021; 4(2):e2036687. PMC: 7881356. DOI: 10.1001/jamanetworkopen.2020.36687. View

McHugh R, Votaw V, Sugarman D, Greenfield S . Sex and gender differences in substance use disorders. Clin Psychol Rev. 2017; 66:12-23. PMC: 5945349. DOI: 10.1016/j.cpr.2017.10.012. View

Murray C . The Global Burden of Disease Study at 30 years. Nat Med. 2022; 28(10):2019-2026. DOI: 10.1038/s41591-022-01990-1. View

10.

Papp M, Leff J, Murphy S, Yang A, Crane H, Metsch L . Harmonizing healthcare and other resource measures for evaluating economic costs in substance use disorder research. Subst Abuse Treat Prev Policy. 2021; 16(1):32. PMC: 8033702. DOI: 10.1186/s13011-021-00356-z. View

11.

Rusby J, Light J, Crowley R, Westling E . Influence of parent-youth relationship, parental monitoring, and parent substance use on adolescent substance use onset. J Fam Psychol. 2018; 32(3):310-320. PMC: 5920742. DOI: 10.1037/fam0000350. View

12.

Siringil Perker S, Chester L . The Justice System and Young Adults With Substance Use Disorders. Pediatrics. 2021; 147(Suppl 2):S249-S258. DOI: 10.1542/peds.2020-023523H. View