Basic Biology and Roles of CEBPD in Cardiovascular Disease

Overview

Journal Cell Death Discov

Date 2025 Mar 15

PMID 40087290

Authors

Tongjun Li

Shaoling Lin

Yingyin Zhu

Dewei Ye

Xianglu Rong

Lexun Wang

Affiliations

Soon will be listed here.

Abstract

CCAAT/enhancer-binding protein delta (CEBPD), as an evolutionarily conserved protein in mammals, belongs to the CEBP transcription factor family, which modulates many biological processes. The diversity of CEBPD functions partly depends on the cell type and cellular context. Aberrant CEBPD expression and activity are associated with multiple organ diseases, including cardiovascular diseases. In this review, we describe the basic molecular biology of CEBPD to understand its expression regulation, modifications, and functions. Here, we summarize the recent advances in genetically modified animals with CEBPD. Finally, we discuss the contribution of CEBPD to cardiovascular diseases and highlight the strategies for developing novel therapies targeting CEBPD.

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