Tissue Specificity of Ageing in Cancer Risk Prediction

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2025 Mar 14

PMID 40082709

Authors

Mark A LaBarge

Alexandra M Binder

Affiliations

Soon will be listed here.

References

Lopez-Otin C, Pietrocola F, Roiz-Valle D, Galluzzi L, Kroemer G . Meta-hallmarks of aging and cancer. Cell Metab. 2023; 35(1):12-35. DOI: 10.1016/j.cmet.2022.11.001. View

Guo J, Huang X, Dou L, Yan M, Shen T, Tang W . Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct Target Ther. 2022; 7(1):391. PMC: 9755275. DOI: 10.1038/s41392-022-01251-0. View

Rode L, Nordestgaard B, Bojesen S . Long telomeres and cancer risk among 95 568 individuals from the general population. Int J Epidemiol. 2016; 45(5):1634-1643. DOI: 10.1093/ije/dyw179. View

Haycock P, Burgess S, Nounu A, Zheng J, Okoli G, Bowden J . Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol. 2017; 3(5):636-651. PMC: 5638008. DOI: 10.1001/jamaoncol.2016.5945. View

Demanelis K, Jasmine F, Chen L, Chernoff M, Tong L, Delgado D . Determinants of telomere length across human tissues. Science. 2020; 369(6509). PMC: 8108546. DOI: 10.1126/science.aaz6876. View

Dugue P, Bassett J, Wong E, Joo J, Li S, Yu C . Biological Aging Measures Based on Blood DNA Methylation and Risk of Cancer: A Prospective Study. JNCI Cancer Spectr. 2021; 5(1). PMC: 7791618. DOI: 10.1093/jncics/pkaa109. View

Levine M, Lu A, Chen B, Hernandez D, Singleton A, Ferrucci L . Menopause accelerates biological aging. Proc Natl Acad Sci U S A. 2016; 113(33):9327-32. PMC: 4995944. DOI: 10.1073/pnas.1604558113. View

Yamamoto R, Chung R, Vazquez J, Sheng H, Steinberg P, Ioannidis N . Tissue-specific impacts of aging and genetics on gene expression patterns in humans. Nat Commun. 2022; 13(1):5803. PMC: 9530233. DOI: 10.1038/s41467-022-33509-0. View

Slieker R, Relton C, Gaunt T, Slagboom P, Heijmans B . Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception. Epigenetics Chromatin. 2018; 11(1):25. PMC: 5975493. DOI: 10.1186/s13072-018-0191-3. View

10.

Sayaman R, Miyano M, Carlson E, Senapati P, Zirbes A, Shalabi S . Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility. Elife. 2024; 13. PMC: 11723586. DOI: 10.7554/eLife.95720. View

11.

Shalabi S, Miyano M, Sayaman R, Lopez J, Jokela T, Todhunter M . Evidence for accelerated aging in mammary epithelia of women carrying germline or mutations. Nat Aging. 2022; 1(9):838-849. PMC: 8849557. DOI: 10.1038/s43587-021-00104-9. View