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Convergent Synthesis of Steviol Glycosides Rebaudioside a and M

Overview
Journal Carbohydr Res
Publisher Elsevier
Date 2025 Mar 13
PMID 40081115
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Abstract

Steviol glycosides, a natural health-focused sweetener, is receiving increasing attention. Herein, an efficient and concise approach for the convergent synthesis of Rebaudioside A and M has been devised. This method features a AuCl-tBuCN cooperative catalysis to achieve highly 1, 2-trans stereoselective glycosidation of a C2-branched trisaccharide trichloroacetimidate with tertiary C-13 hydroxy group in steviol aglycone, without relying on neighboring group participation.