Convergent Synthesis of Steviol Glycosides Rebaudioside a and M
Overview
Overview
Journal
Carbohydr Res
Publisher
Elsevier
Specialties
Biochemistry
Endocrinology
Endocrinology
Date
2025 Mar 13
PMID
40081115
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Steviol glycosides, a natural health-focused sweetener, is receiving increasing attention. Herein, an efficient and concise approach for the convergent synthesis of Rebaudioside A and M has been devised. This method features a AuCl-tBuCN cooperative catalysis to achieve highly 1, 2-trans stereoselective glycosidation of a C2-branched trisaccharide trichloroacetimidate with tertiary C-13 hydroxy group in steviol aglycone, without relying on neighboring group participation.