Enhanced Antioxidant and Protective Effects of Fermented L. Peel Extracts Against Ultraviolet B-Induced Skin Damage

Overview

Journal Nutrients

Date 2025 Mar 13

PMID 40077718

Authors

Joo Hwa Lee

Jinsick Kim

Yu Chang Jo

Yun Hoo Jo

Yeong Hwan Jeong

Soo Ah Jeong

Beong Ou Lim

Dong Wook Shin

Affiliations

Soon will be listed here.

Abstract

: The skin, being the body's outermost organ, plays a vital role in protecting against various external stimuli. Ultraviolet generates reactive oxygen species (ROS), promoting the secretion of matrix metalloproteinases (MMPs) and inducing collagen degradation. Many studies have been conducted to identify natural substances that can prevent or delay the harmful effects of UV. : A wound healing assay, DCF-DA reactive oxygen species (ROS) assay, and JC-1 assay were performed to assess the effects of bio-converted eggplant peels (BEPs) on human dermal fibroblasts (HDFs). Western blot analysis was also conducted to understand the underlying mechanisms for their effects. Finally, hematoxylin-eosin staining and immunohistochemistry were also performed in animal studies. : Our study evaluated the antioxidant efficacy of BEPs fermented with in hydrogen peroxide (HO)-HDFs and UVB-induced skin damage in hairless mice. We demonstrated that BEPs exhibited enhanced antioxidant properties compared to non-fermented eggplant peels (EPs). BEPs facilitated wound healing in HO-damaged HDFs, reduced ROS levels, and restored mitochondrial membrane potential. BEPs suppressed the phosphorylation of ERK, p38, and JNK as their underlying mechanism. We further demonstrated that dietary supplementation of BEPs also downregulated matrix metalloproteinase 1 (MMP1) expression and upregulated collagen I (COL1) in UVB-damaged hairless mice, indicating that BEPs were more effective compared to EPs. : Our studies suggest that BEPs fermented with hold significant potential as a protective agent for mitigating UVB-induced damage and promoting skin health.

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