A Retrospective Analysis of the Changes in Prediabetes-Associated Markers of Thyroid Function in Patients from Durban, South Africa

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2025 Mar 13

PMID 40076791

Authors

Hasnaa Satar Aswani

Wendy Mdluli

Andile Khathi

Affiliations

Soon will be listed here.

Abstract

Thyroid dysfunction and type 2 diabetes melittus (T2DM) are two of the most common endocrine disorders, and the emerging condition of prediabetes necessitates additional research to better understand the complex interactions between thyroid hormones, metabolic regulation, and the progression from prediabetes to T2DM. This study sought to investigate changes in selected markers of thyroid function in patients with pre-diabetes. Upon obtaining ethics permission, blood samples were collected from patients in King Edward Hospital in Durban, South Africa. The samples were classified as non-diabetic, pre-diabetic, and type 2 diabetic using the ADA guidelines. The thyroid stimulating hormone (TSH), thyroxine (T4) triiodothyronine (T3), Thyroglobulin (TG), and thyroid peroxidase antibody (TPOAb) concentrations were determined in these samples. The results showed elevated TSH, decreased T3 and T4, decreased thyroglobulin (Tg), and elevated TPOAb in the prediabetic group which became considerably pronounced with the shift to T2DM. The alterations in these markers during prediabetes may indicate an early stage of thyroid dysfunction necessitating further investigation as these alterations become more pronounced during type 2 diabetes mellitus.

References

Mondal S, Raja K, Schweizer U, Mugesh G . Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones. Angew Chem Int Ed Engl. 2016; 55(27):7606-30. DOI: 10.1002/anie.201601116. View

Sosibo A, Mzimela N, Ngubane P, Khathi A . Prevalence of pre-diabetes in adults aged 25 - 45 years in a Durban-based clinical setting, South Africa: A retrospective study. Prim Care Diabetes. 2023; 17(6):650-654. DOI: 10.1016/j.pcd.2023.10.004. View

Kohrle J . Thyroid hormone transporters in health and disease: advances in thyroid hormone deiodination. Best Pract Res Clin Endocrinol Metab. 2007; 21(2):173-91. DOI: 10.1016/j.beem.2007.04.001. View

Mzimela N, Sosibo A, Ngubane P, Khathi A . Investigation into changes in inflammatory and immune cell markers in pre-diabetic patients from Durban, South Africa. J Immunotoxicol. 2023; 21(1):2290282. DOI: 10.1080/1547691X.2023.2290282. View

Ha J, Lee J, Lim D, Lee J, Chang S, Kang M . Association of serum free thyroxine and glucose homeostasis: Korea National Health and Nutrition Examination Survey. Korean J Intern Med. 2020; 36(Suppl 1):S170-S179. PMC: 8009147. DOI: 10.3904/kjim.2019.160. View

McLachlan S, Rapoport B . Thyroid peroxidase as an autoantigen. Thyroid. 2007; 17(10):939-48. DOI: 10.1089/thy.2007.0169. View

Oda T, Taneichi H, Takahashi K, Togashi H, Hangai M, Nakagawa R . Positive association of free triiodothyronine with pancreatic β-cell function in people with prediabetes. Diabet Med. 2014; 32(2):213-9. DOI: 10.1111/dme.12589. View

. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2021; 45(Suppl 1):S17-S38. DOI: 10.2337/dc22-S002. View

da Silva Teixeira S, Panveloski-Costa A, Carvalho A, Monteiro Schiavon F, Ruiz Marque A, Campello R . Thyroid hormone treatment decreases hepatic glucose production and renal reabsorption of glucose in alloxan-induced diabetic Wistar rats. Physiol Rep. 2016; 4(18). PMC: 5037915. DOI: 10.14814/phy2.12961. View

10.

McAninch E, Bianco A . Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci. 2014; 1311:77-87. PMC: 4451242. DOI: 10.1111/nyas.12374. View

11.

Duntas L, Orgiazzi J, Brabant G . The interface between thyroid and diabetes mellitus. Clin Endocrinol (Oxf). 2011; 75(1):1-9. DOI: 10.1111/j.1365-2265.2011.04029.x. View

12.

Gu L, Yang J, Gong Y, Ma Y, Yan S, Huang Y . Lower free thyroid hormone levels are associated with high blood glucose and insulin resistance; these normalize with metabolic improvement of type 2 diabetes. J Diabetes. 2020; 13(4):318-329. DOI: 10.1111/1753-0407.13118. View

13.

Grigoriadis G, Koufakis T, Kotsa K . Epidemiological, Pathophysiological, and Clinical Considerations on the Interplay between Thyroid Disorders and Type 2 Diabetes Mellitus. Medicina (Kaunas). 2023; 59(11). PMC: 10673571. DOI: 10.3390/medicina59112013. View

14.

Jing S, Xiaoying D, Ying X, Rui L, Mingyu G, Yuting C . Different levels of thyroid hormones between impaired fasting glucose and impaired glucose tolerance: free T3 affects the prevalence of impaired fasting glucose and impaired glucose tolerance in opposite ways. Clin Endocrinol (Oxf). 2013; 80(6):890-8. DOI: 10.1111/cen.12384. View

15.

Carvalho D, Dupuy C . Thyroid hormone biosynthesis and release. Mol Cell Endocrinol. 2017; 458:6-15. DOI: 10.1016/j.mce.2017.01.038. View

16.

Eom Y, Wilson J, Bernet V . Links between Thyroid Disorders and Glucose Homeostasis. Diabetes Metab J. 2022; 46(2):239-256. PMC: 8987680. DOI: 10.4093/dmj.2022.0013. View

17.

Khassawneh A, Al-Mistarehi A, Zein Alaabdin A, Khasawneh L, AlQuran T, Kheirallah K . Prevalence and Predictors of Thyroid Dysfunction Among Type 2 Diabetic Patients: A Case-Control Study. Int J Gen Med. 2020; 13:803-816. PMC: 7568427. DOI: 10.2147/IJGM.S273900. View

18.

Santos-Palacios S, Brugos-Larumbe A, Guillen-Grima F, Galofre J . A cross-sectional study of the association between circulating TSH level and lipid profile in a large Spanish population. Clin Endocrinol (Oxf). 2013; 79(6):874-81. DOI: 10.1111/cen.12216. View

19.

Gidey G, Hiruy M, Teklu D, Ramanathan K, Amare H . Prevalence of Prediabetes and Related Modifiable Cardiovascular Risk Factors Among Employees of Ayder Comprehensive Specialized Hospital, Tigray, Northern Ethiopia. Diabetes Metab Syndr Obes. 2023; 16:643-652. PMC: 10008371. DOI: 10.2147/DMSO.S307823. View

20.

Zhang Y, Lu P, Zhang L, Xiao X . Association between lipids profile and thyroid parameters in euthyroid diabetic subjects: a cross-sectional study. BMC Endocr Disord. 2015; 15:12. PMC: 4379692. DOI: 10.1186/s12902-015-0008-3. View