Endoscopic Ultrasound-Guided Anastomoses of the Gastrointestinal Tract: A Multicentric Experience

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2025 Mar 13

PMID 40075757

Authors

Giacomo Emanuele Maria Rizzo

Chiara Coluccio

Edoardo Forti

Alessandro Fugazza

Cecilia Binda

Giuseppe Vanella

Francesco Maria Di Matteo

Stefano Francesco Crino

Andrea Lisotti

Marcello Fabio Maida

Giovanni Aragona

Aurelio Mauro

Alessandro Repici

Andrea Anderloni

Carlo Fabbri

Ilaria Tarantino

The I-Eus Group

Affiliations

Soon will be listed here.

Abstract

This multicenter retrospective study included patients undergoing EUS-guided GI anastomoses from 2016 to 2023. Indications for EUS-guided anastomosis were GOO, ALS or patients with altered anatomy needing endoscopic interventions. The primary outcome was technical success, while secondary outcomes included clinical success, safety, lumen-apposing metal stent (LAMS) patency, and the need for reinterventions. A total of 216 patients (mean age 64.5 [±13.94] years; 49.1% males) were included. In total, 149 cases (69%) were GOO, 44 (20.4%) cases were bilioenteric anastomotic strictures or lithiasis in altered anatomy, 14 cases (6.5%) were ALS, and 9 patients (4.2%) were for ERCP in altered anatomy after EUS-GG. Overall, EUS-GE was performed in 181 patients (83.8%), EUS-JJ in 44 cases (20.4%), and EUS-GG in 10 (4.6%). Technical success was 94.91%, and clinical success was 93.66%. The adverse event (AE) rate was 11.1%. The reintervention rate was 7.69%. The median follow-up was 85 days. In conclusions, EUS-guided GI anastomoses are technically feasible and safe in both malignant and benign diseases.

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